Continuity mistake: Ms. Krabapple takes the cellular devices from the children in her class and puts them in a Laramie Cigarette box. She dumps the box into a desk drawer filled with frogs. A few seconds later there is a shot of the class from her point of view with all of their cellular devices on their desks.
Continuity mistake: When Homer is shot at the hippie farm, he ends up with a flower in his head, stem first. But he put the flower in the gun barrel stem first, as well. From a shot at that close a range and that velocity, there's no way the flower could have turned around in mid-air.
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Plot hole: In "Life's a Glitch", Lisa finds out that she has a seat on the spacecraft going to Mars as the proofreader. How, though, was she not informed of this before going to the rocket? The family only finds out about the rocket after finding Krusty's letter/invitation and the fact that she was on the list there would be no reason why she wouldn't have been informed of this. It was still New Year's Day so if it had been by mail then it would have to arrive before the New Year so as to make the plan work, being as it was a public holiday and no mail would be delivered. Therefore it would have to be delivered personally or someone would need to contact her. There were also many well known celebrities and figures ready to board the rocket. I can't imagine they were all home in time to gather their mail and were all somehow contacted, yet Lisa was simply walking around town and at church and they couldn't find her? There was also no evidence to suggest anything would have stopped her from either receiving the invitation in time or being informed of the mission.
Audio problem: In the scene where Lisa is presenting her bully repellant at the 'Big Science Thing', when she first walks onstage there are murmurs of disapproval among the scientists, in which you can hear one of them saying, "Let's not listen". But after Lisa sprays the repellant on herself and stops Francine in her tracks, the scientists start murmuring in astonishment. However, if you listen closely, you'll hear the same recording of someone saying, "Let's not listen".
Continuity mistake: When the Simpsons are on the raft going down the river in Africa they come to a fork and have a choice of going to the left, towards a sunny and nicer area or to the right where it is rainy and gloomy. As Homer tries to steer the raft to the left as he pulls his left arm out of the water and it is covered in leeches but in the next shot of him when we see the arm again the leeches are gone. No way to remove leeches that fast.
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Revealing mistake: After Lisa says "For a product that's evil and deadly" while standing in front of the tomacco stand, there's a duplicate Lisa behind her that stands still while she moves, giving Lisa the appearance of having two heads. It looks like the animators made a mistake while trying to animate Lisa.
Other mistake: In the DVD booklet, two errors are made for this episode. The booklet says Homer accuses Bart of ruining Thanksgiving and Bart was jealous of Lisa's centre piece. These are both incorrect: First, it wasn't Homer who accused Bart of ruining Thanksgiving, it was Marge who accused Bart of ruining Thanksgiving and second, at no point throughout the episode was Bart ever jealous of Lisa's centre piece.
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