Continuity mistake: When Kevin goes to the grocery, he buys Tide detergent. While walking home, the two bags break, but no Tide detergent falls out.
Continuity mistake: There's an electrical outlet on the wall below the window (aligned with the window shade's loop) in Sid's room near the Megadork poster, but when Sid throws Woody to the floor and raises the shade (before he scorches Woody's forehead with the magnifying glass), that outlet has vanished.
Plot hole: Isn't it rather strange that nobody outside the Howard family's small town expresses any interest in the confirmed discovery of a new human sub-species, the only one on the planet? Wouldn't it be more likely that their little backwater town would be inundated with every press and scientific organisation on earth, and that the Howard family would be the centre of the greatest publicity carnival of all time?
Factual error: Near the end of the film Knox is flying a Huey helicopter and the Angels hitch a ride by shooting it with a spear gun and dangling on the line behind it. Suddenly adding about 200kgs to a Huey in flight like that is going to cause all sorts of problems with the trim and airspeed of the aircraft - the pilot would know immediately that something was wrong. (01:23:20)
Continuity mistake: As Buddy walks out into the street at the start of the movie when the cat is playing dead, you can see several parked cars on the street behind him. When the van backs up to 'catnap' buddy, there are no parked cars. Then as the van drives off again, there is a different bunch of parked cars in the street. (00:03:54)
Continuity mistake: During his conversation with the director, while discussing his costuming, Dalton's hair changes from messy and curled to gelled up and straight.
Factual error: It is not possible to be "allergic to all known anaesthetics". Amongst the amide local anesthetics lidocaine, prilocaine, bupivicaine, mepivacaine and dibucaine are naturally occurring substances and if administered without a preservative they cannot trigger an allergic reaction. If Bales is allergic to them, he'd be allergic to the metabolic processes of his own body. They are all powerful local anaesthetics and could easily be used for a radical rhinoplasty such as that required by Bales.
Revealing mistake: When Austin enters the bathroom at the casino, keep your eyes on the door during the scene - it opens by itself before closing. (00:31:10)
Continuity mistake: In the bedroom scene the girl is holding a clear cup full of beer. The camera goes off her and when it comes back she is holding a blue cup. The camera goes back off her then on her and the cup is clear again. [This mistake does not appear in the unrated version - the blue cup scenes were shot specifically to secure an R rating from the MPAA because the contents are obscured.]. (00:13:20)
Factual error: While Bridger is watching the film of the Mafia boss following Beckerman he signals for the film to be stopped so he can look at the close up shot of the man. He is watching a 16mm film shown through a bog standard projector - stop a film like that for more than two seconds without closing down the projector shutter (this doesn't happen - if it did the screen would darken instantly) and it will melt and catch fire. This doesn't happen.
Visible crew/equipment: When Pee Wee is chaining up his beloved bike you can see the long chain coming up through the bottom of the bike box. Full screen version only. (00:13:40)
Other mistake: When Adam comes in and says "when I woke up this morning, the pain was gone", Connie is mouthing his lines behind him.