Continuity mistake: At the very end of the episode, when Homer is being carried off by the crowd, you can see that the crowd carrying Homer, the people are small, so you'll have to look closely, but right before the credits, Marge's necklace changes from red to white, back to red and then finishes with white all in one shot. (00:21:00)
Other mistake: In the scene where the Simpsons are viewing the path of the Corvair's Re-entry, the blip representing the spaceship crosses the entire US from North-West to South-East in about three seconds. This is really impossible, even for something going as fast as a spaceship on re-entry would be.
Continuity mistake: When the Stonecutters are singing "We do", the position of several characters, particularly Number 51 and Chief Wiggum, change randomly as the camera angles change. Number 51 starts at the end of the table on the right side, with Chief Wiggum two seats to the left of him. In later shots, Number 51, then Wiggum are both switched to the same position, midway up the left side. Then, when the song ends, Wiggum has disappeared, and Number 51 remains in this new position.
Continuity mistake: After Kirk (Milhouse's dad) drives away from the stadium, Bart and Homer are walking along and you can see the Drink Duff sign right next to the edge of the fence. The next shot of Homer noticing the sign, the sign is further away from the edge of the fence and is smaller.