Continuity mistake: After Dr. Sayer and Leonard get ice cream and go to Dr. Sayer's home, Leonard is sitting on the couch and on the table in front of him is a plate of saltine crackers. The amount of crackers and the way they are lying on the plate change.
The drug wears off, and the patients all go back to their comatose state, including Robert DeNiro. Robbin Williams is nonetheless encouraged, since he at least discovered what the illness was. He finally invites the nurse out for coffee.
Trivia: During the scene where Robin Williams (the doctor) has to restrain Robert DeNiro (the patient), Robin accidentally broke DeNiro's nose. DeNiro insisted that they continue with the filming until the scene was completed because he knew, from prior experience, that he wouldn't be able to film for at least a week, until the swelling and bruising went down. And DeNiro actually was glad it happened because it corrected the bump from the prior broken nose.
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