Continuity mistake: When the person delivers the animation cell, his skin changes from white, to brown and then back to white. When Bart looks through the letterbox to see who was there, his skin is white. When he gives the box to Bart, it is brown. When he hits Bart in the face and says "that's for keeping me waiting", it is white again.
Continuity mistake: John is wearing Homer's old "Pin-pals" bowling shirt when the Simpsons first meet him, but only after we see the back of the shirt does the name "Homer" appear over John's breast-pocket; clearly there was nothing there during their entire previous conversation. And even if this is a deliberate "mistake" for comic purposes, in 7th season episode"Team Homer", the very same bowling shirt is ripped to shreds when Homer is being mauled by Mr.Burns' dogs at the very end.
Continuity mistake: In the 'Nightmare on Evergreen Terrace' segment, in Bart's dream you see a shadow of what looks like someone with four knife-fingers. Then when we see who it is, it is Willie holding a rake. But the rake has five tines, not four, so the shadow is wrong. (00:07:00)Hamster
Continuity mistake: In the episode which recalls how Homer and Marge got married, Homer writes a note to Marge on a piece of paper entitled 'From The Pen Of Patty' he SCRIBBLES out Patty's name and writes his own, but when Marge reads the note, 'Patty' only has a single straight line through it. The word "HOMER" also changes.