Continuity mistake: In the beginning after Maggie hit Homer on the head, it shows him laying on the couch with Bart & Lisa on the left. The next shot it shows the TV, in the next shot it shows Homer on the left sitting and Bart & Lisa on the right. It's impossible for Homer to get up and switch sides with Bart And Lisa in less than 5 seconds.
Continuity mistake: When one of the pockets of Marge's coat explodes (when Homer is stealing the rare Gummi), a huge pile of candy comes pouring out. When she bends down to pick some up, there isn't nearly as much candy there as before. There are people picking up the candy with her, but they would have to pick it up extremely fast, and they aren't.
Continuity mistake: When Homer and Marge think they have finally got away from Bart and Lisa and Homer is about to look in the dinner bowl, on the table holding the food there is a bottle of champagne and two glasses, yet when Bart and Lisa jump out the 3 things have vanished.
Continuity mistake: At the beginning of the show, the hospital Mr. Burns is at has a sign in front of it that reads, "Got Tumor?", but when we see the hospital again it isn't there. Additionally, the "Mayo Clinic" sign atop the building gets noticeably smaller in the second shot.