Continuity mistake: In "Krusty Gets Busted", Krusty's natural skin colour is established as yellow. In "Brush With Greatness" we see him wiping off the clown makeup to reveal that he has yellow skin. But in "Homer's Triple Bypass", he comes to visit Homer, with his white clown face, and tells him that "this isn't make-up". Other episodes after that also show that his skin is white.
Continuity mistake: In the beginning, the family is eating in front of the T.V. When Marge is complaining about getting the food all over the floor, she drops her meatball on the floor, and it leaves a trail of sauce on the rug. In the bird's eye view of the room, the sauce has disappeared until the shot changes: then it reappears.