Continuity mistake: Bart opens the house's front door, then the shot zooms out to show us that all of Springfield is at the Simpson house. In the next shot with Mayor Quimby the door is suddenly closed. (00:15:30)
Continuity mistake: During Tom Savini's presentation, the comic book seller eats a kind of cookie. Fake blood then start to flows from his mouth and he takes his t-shirt to wipes it. There are no stains on it after that.
Tree House of Horror VIII - S9-E4
Continuity mistake: Mutant Moe had one red mark on his face wile talking to Homer in the church, but when everyone attacks him, he has two.
Tree House of Horror X - S11-E4
Continuity mistake: In "I Know What You Diddly-Iddly Did", there are a few errors: Homer says, "Guess I forgot to put the fog lights in" at a slightly higher pitch to when we heard him say it earlier (When the event actually happened). When Marge actually ran over Ned she did not carry on driving. The flashback shows that Ned was run over without glasses. However in the actual event he had glasses on.
Tree House of Horror XII - S13-E1
Continuity mistake: At the end of 'Hex and the City,' there is a shot of the wedding cake, then it pans across the people at the wedding, and you can see Homer with his white shirt on. But then when it goes to a closeup, he suddenly has a blue suit and tie on. (00:06:45 - 00:07:20)
Skinner's Sense of Snow - S12-E8
Continuity mistake: When the Hamster rolls through the glass of Flanders car it breaks it near the bottom middle of The Front windshield. Later on when Flanders and Homer are taking the kids home you can see the break in the glass has now moved to about halfway up The Front windshield. On of the following shots it moves back to its original position and then moves back to being around the middle of the windshield.
Continuity mistake: At the end of the episode, Homer puts a skull in a box on the coffee table. When Moe arrives to explain his theory, first the box disappears from the coffee table, then the entire table vanishes.
Continuity mistake: When it is announced that Amber is the winner of the contest, and Lisa is runner-up, the stands in the back of the stage are empty. However, when Lisa walks off, all the contestants are back on the stands. (00:15:00)
Continuity mistake: The colour of the alien poster in the nerds' room changes from pink to blue.
Two Dozen and One Greyhounds - S6-E20
Continuity mistake: When they are in Mr Burns' laundry room, it is shown that Bart wasn't wearing his socks. However, part way through this scene, Bart is wearing his shoes and socks again without having time to put them on.
Continuity mistake: When handing out the mail, Marge places a miniature jerry can of petrol on the table. It is gone in the next shot.
Home Away From Homer - S16-E20
Continuity mistake: When Homer tries to leave his seat in the cinema and complains about eating the apple, the shot shows his body fat has wedged him in the seat. However we can see from all the shots before this that the fat was never wedged in like it was when he was trying to leave.
Bart Gets Hit By a Car - S2-E10
Continuity mistake: During Marge's testimony, Lionel Hutz has a neat stack of papers in front of him the whole time. But in the close-up when Homer and Hutz both cover their eyes in sorrow, Hutz has several pieces of crumbled paper and a broken pencil in front of him. The was not nearly enough time for him to make such a mess since the last shot of him.
Homer vs. Patty and Selma - S6-E17
Continuity mistake: At the beginning of the episode, there is a drunk wearing glasses. He disappears in the next shot onwards.
Fat Man and Little Boy - S16-E5
Continuity mistake: When Bart is playing with his toys, we see that in one shot on the shelf there are 4 books, then in the next shot there are 5. (00:03:50)
Continuity mistake: When Bart attempts to skate over Homer's car, his three mates are watching. Between shots they change from standing on the driveway to standing on the pavement. (00:10:55)
Continuity mistake: Wiggum asks Homer for another burger and Homer throws it to him. When he catches it Otto has disappeared from sitting next to Eddie.
Much Apu About Nothing - S7-E23
Continuity mistake: In the final high-up shot of the Simpson's garden with everyone chanting 'No on 24'; Lisa has disappeared from next to Apu, and Ned Flanders' glasses have vanished.
Tree House of Horror II: A Simpsons Halloween - S3-E7
Continuity mistake: After Maggie makes her wish, the family jumps from being in their seats to beside the window. (00:03:50)
Answer: I'm not sure if this is the one you're thinking of, but an episode of "Ray Bradbury Theatre," called "A Sound of Thunder," dealt with a similar matter: a group of hunters travel back in time to hunt dinosaurs, only to find things have changed when they get back because someone stepped on a butterfly.
Xofer