Audio problem: In the scene where the Be Sharps first sing "Coney Island Babe" (I don't know what the song's really called) at Moe's, Skinner sings the rhythm. But when they sing the last few lines, you can still hear Skinner's part, but his mouth is moving like the rest of the group.
Audio problem: In the scene where Lisa is presenting her bully repellant at the 'Big Science Thing', when she first walks onstage there are murmurs of disapproval among the scientists, in which you can hear one of them saying, "Let's not listen". But after Lisa sprays the repellant on herself and stops Francine in her tracks, the scientists start murmuring in astonishment. However, if you listen closely, you'll hear the same recording of someone saying, "Let's not listen".