Audio problem: When Principal Skinner is watching the kids throw the books in the fire, someone goes to throw Huckleberry Finn into the fire. He says "Not Huck Finn. I spent hours crossing out the sass-back." While he says this, his lips don't sync with the words.
Audio problem: In the scene where Lisa is presenting her bully repellant at the 'Big Science Thing', when she first walks onstage there are murmurs of disapproval among the scientists, in which you can hear one of them saying, "Let's not listen". But after Lisa sprays the repellant on herself and stops Francine in her tracks, the scientists start murmuring in astonishment. However, if you listen closely, you'll hear the same recording of someone saying, "Let's not listen".