Character mistake: In the cutaway gag involving George and Lorraine McFly from "Back To The Future" Lorraine says she hasn't seen Marty from high school since prom. George, Lorraine and Marty all attended the Enchantment Under the Sea dance in November 1955, not the prom, which is usually held in the spring.
Continuity mistake: In the cutaway of Brian in the Old Yeller remake, he takes out a gun and goes to shoot a boy. When he first fires, the shell from the first gunshot lands on the ground beside him, but in the next shot, the shell has suddenly rotated itself by about 90° to the left.
Continuity mistake: When Peter returns home from being hyped up on Red Bull, he has numerous cans in his arms. When he sees Stewie he immediately drops the cans on the floor but when the camera pulls back as he sits down with Stewie in his lap, the cans of Red Bull are nowhere to be seen.
Continuity mistake: In the cutaway of Stewie talking with the three co-workers at the factory, there is a man towards the left of shot, leaning against a forklift. Beside the man is a female factory worker sitting on a crate about three to four feet to the left of him and her lunchbox is on the ground in front of the crate. In the next shot, as Stewie walks back to his forklift, the crate the woman is sitting on and the lunchbox are a much further distance from the man. The shot then pulls out, and the woman and her lunchbox are suddenly back to the original distance.
Character mistake: When the family is about to drown in the panic room and start arguing with Peter about not liking "The Godfather," Chris starts listing off the great actors in it. "Robert DeNiro, Al Pacino, I mean, you've never seen...ROBERT DUVALL!" Robert DeNiro is in "The Godfather Part II," but not in the first one. (00:19:30)
Factual error: In the park, Stewie and Brian are playing the "water pipes" like a xylophone. Trouble is, in order to get the tones they were playing, the glasses should have had different levels of water in them. If you look closely, all the glasses have the same level of water.