Continuity mistake: When they finally arrive at the bottom of the sewer, Eddie's bandage is on a different cheek. (01:59:00)
Continuity mistake: When the real 'manager' comes outside to yell at "Mr. O'Donnell', you see the manager walk back into the club. If you look in the background of the next shot, you can see the manager walking through the door again. (00:13:25)
Factual error: Towards the end of the movie when Andy is escaping, he breaks open a sewage pipe and is covered with its contents. It is physically impossible for the sewage to shoot out of the break like it did. In order for that to happen there has to be pressure. But there is none there, because the end he crawls through is empty and the end is in the open air. (01:52:20)
Continuity mistake: In the final battle, Wasp and Ant-Man are in the van trying to get the quantum tunnel operational. We cut back to the fight and we can see Ant-Man there too, fighting in his giant form. (02:22:20 - 02:23:00)
Continuity mistake: At the beginning when Indy is talking to Spalko, his hands keep alternating from being in his pockets to just resting at his sides between shots.
Revealing mistake: Gracie hugs the Russian waitress in order to have a better view of the disc hand-off appear on the monitor. As she raises her left hand that holds the book/camera lens, we see that the digital feed that appears on the monitor stays steady and level, even though she is raising the book/camera lens higher and closer to her face. Obviously the feed that we see on the monitor is not taken from the book/camera lens. (00:04:10)Super Grover
Other mistake: Murphy lands the helicopter on a railway line so an oncoming train will destroy it completely, and this happens exactly on cue with huge, dramatic explosions and flying debris. Apparently the train driver doesn't think this is important enough to interrupt his busy schedule - he doesn't stop the train. We do not hear brakes being applied - the wheels would make a noise like the sky coming down - and the train doesn't slow down at all - it just keeps on going.
Plot hole: Lucy jumps from the airliner and flies her hang-glider straight to Eduardo/El Macho's Cinco de Mayo party to find Gru. How did she know Gru would be there? He had no intention of going and only did so after he was pestered into it by the girls on the very night of the party, so he couldn't have told her himself. Shouldn't she have gone to his house instead? (01:09:50)
Continuity mistake: In the first film, it is mentioned several times that Kevin is 8 years old. However, in this film it is stated that he is 10. When his parents are in the Miami airport security office, they say that he was left alone last Christmas. That would make him 9. Both films take place the same days, from about three days before Christmas until Christmas morning, so even if Kevin is born around Christmas time this is still a mistake.
Continuity mistake: In the latter half of the movie, Picard looks at a picture of himself from his days as a Starfleet Academy cadet while Beverly looks on too. This picture is actually the actor Tom Hardy (Shinzon, Picard's clone) and he appears with a completely bald/shaved head. Showing Picard bald as a cadet completely contradicts the TNG series. In the TNG episode 'Tapestry', a flashback set in 2327 (the year Picard graduated from the Academy), Picard is shown with a full head of hair. Also, in the TNG episode 'Violations', a flashback set in 2354 shows Picard with a partial head of hair when he takes Beverly to see her dead husband Jack's body. (00:46:25)
Visible crew/equipment: When C-3PO is on the conveyor belt, if you look in the reflection in his head you can see the camera crew.
Continuity mistake: When Layla is hooked up to the lie detector that tracks the movement of her eye, she is looking around the room and blinking repeatedly, but the eye on the screen (which is supposed to be hers) never moves or blinks, even though the camera is still on her.
Continuity mistake: The tiger bites the seat off the suitor's trousers, allowing the viewer to see his polka-heart boxers. When we see the tiger in the courtyard, he has a part of the same boxer shorts in his mouth. So if he bit off the seat of the trousers, shouldn't he have purple cloth in his mouth? (00:11:45)
Other mistake: In the scene where the kids are shooting arrows and the coach gets hit by one, they send a girl to call 911. If you look closely and follow her in the background, after she runs a few yards, she slows down and eventually stops and stands there playing with her hair. Talk about help... (00:57:05)