Continuity mistake: In the episode which recalls how Homer and Marge got married, Homer writes a note to Marge on a piece of paper entitled 'From The Pen Of Patty' he SCRIBBLES out Patty's name and writes his own, but when Marge reads the note, 'Patty' only has a single straight line through it. The word "HOMER" also changes.
Continuity mistake: When Burns first shows the team the nerve tonic, the "&" on the 'Brain & Nerve Tonic' label is facing backward, but as Burns pulls it away it faces forward. Then as he moves it around as he's talking, the "&" switches between facing forward and facing backward again. This happens all in the one shot.
Continuity mistake: The photo Edna sends to Bart differs when he shows his parents. The angle is different from what it was previously, revealing part of a photo frame on the wall which wasn't there before, and the sheets/pillows on the bed are different, and her eyes are closed when they look at it, but when Bart looked at it, they were open. (00:09:05 - 00:18:25)Hamster
Continuity mistake: Bart's guitar is lefthanded. So when the righthanded Otto plays it on the bus, the guitar is flipped over, with the little speaker on the top. But when Otto is playing it later in the garage, it is a normal righthanded guitar, with the little speaker on the bottom.
Continuity mistake: This is a mistake for the introduction from seasons 2-20 (1991-2009). When Homer screams, he turns round. You see this in a wide shot. There are no boxes to the right of the door in the garage. However, two just appear out of thin air when he runs through the garage. (00:01:50)