The Retraction Reaction - S11-E2
Character mistake: When speaking on the radio, Leonard says he has never heard himself through headphones. We have seen him several time wearing headphones while speaking, for example during a podcast with Will Wheaten and on Science Friday too.
The Big Bran Hypothesis - S1-E2
Continuity mistake: At the end of the episode, when the gang is reading the furniture assembly instructions, a pencil in the cup in front of them suddenly vanishes. (00:19:00)
The Creepy Candy Coating Corollary - S3-E5
Continuity mistake: At the dinner, Howard's mom calls. Howard's wine glass refills itself between shots. (00:15:20)
The Staircase Implementation - S3-E22
Character mistake: In 1-14 "The Nerdvana Annihilation", when Howard says they should put the time machine into the elevator, Leonard states the elevator had been broken for two years. But in this episode, we found out the elevator broke seven years earlier. (00:03:10)
The Luminous Fish Effect - S1-E4
Continuity mistake: When Penny comes into the apartment to ask if Sheldon needs anything from the market, between the few shots, the position of the napkin and the pile of eggs on the plate he is holding changes. (00:05:15)
Factual error: Every time we see Leonard's laser lab the door is open and he is able, if the story requires it, to fire the laser. As evidenced by the several safety notices visible and the scripted requirements for characters to put on safety goggles it should not be possible to activate the laser while the lab door is open - it would be interlocked, meaning the laser wouldn't function unless the door is closed.
The Large Hadron Collision - S3-E15
Continuity mistake: Penny asks Sheldon if the roommate agreement contains something about girlfriends, which Sheldon dismisses as unrealistic. However, it was revealed in season 2 that there is a cohabitation rider. This was revealed when Sheldon asserted that Leonard's girlfriend, Stephanie, was officially living with them.
The Herb Garden Germination - S4-E20
Other mistake: When Sheldon and Leonard are playing Archery on Wii Sports Resort, Sheldon presses the Z button on the nunchuck controller to fire the arrow, which is incorrect. When Leonard plays, he holds the Z button as he prepares to fire, then releases the Z button to fire, which is the correct controls. (00:03:00)
The Robotic Manipulation - S4-E1
Continuity mistake: In the ER, the glasses around the nurse's neck move instantly without her touching them. They go from angled to straight instantly. (00:17:45)
The Fuzzy Boots Corollary - S1-E3
Continuity mistake: When Sheldon, Howard and Raj play Jenga, there is one block sitting at the top of the tower. When Leonard walks in, there are now two blocks at the top, before we actually see Howard place the second one on the top. (00:08:10)
Continuity mistake: When Penny is squirting chocolate syrup in the ice cream container, she drizzles some on the lip of the carton, causing it to run down the outside. The camera switches to Leonard and then back to Penny, at which point, the chocolate is gone. (00:04:50)
The Zarnecki Incursion - S4-E19
Plot hole: While it would certainly destroy the entire plot of the episode, Sheldon could have simply contacted Blizzard's customer support to get all his stuff back.
The Wildebeest Implementation - S4-E22
Continuity mistake: When Howard, Bernadette, Leonard and Priya are playing Jenga on the coffee table, the silver coffee pot, between the game and a coffee cup, disappears and reappears between shots.
The Irish Pub Formulation - S4-E6
Continuity mistake: As Raj, Howard and Sheldon are sitting at the table discussing leaving Priya alone while Leonard and Priya are away from the table, a water bottle sitting in front of Raj moves back and forth between his tray and Leonard's tray.
The Luminous Fish Effect - S1-E4
Continuity mistake: When Leonard and Sheldon are walking downstairs, Sheldon stops and pins back up the caution tape that is in front of the elevator. Between shots, the other strip of caution tape untwists itself. (00:01:25)
Audio problem: When Sheldon is knocking on Leonard's door at the start, the sound is out of sync with the action.
The Gothowitz Deviation - S3-E3
Character mistake: Sheldon refers to using the spray bottle as negative reinforcement when it is in fact positive punishment. Reinforcement involves encouraging a behaviour by either adding or removing a stimulus whereas punishment involves discouraging a behaviour by adding or removing a stimulus. Sheldon would know the difference.
The Adhesive Duck Deficiency - S3-E8
Character mistake: When Sheldon is placing his order near the beginning of the episode, he states "In the mid-18th century, King Rama IV of Siam..." King Rama IV was born 18th October 1804 and died 1st October 1868. His reign was during the mid-19th century (1851-1868).
Answer: Because Raj's selective mutism seems to be caused by women that Raj sees (on some sort of conscious or subconscious level) as a potential sexual partner. An attribute that wouldn't apply to either his sister or mother.