Character mistake: In his conversation with Missy Sheldon makes it clear that his superior intelligence is a result of a random, mutated gene. Since Missy isn't similarly intelligent she obviously isn't carrying this mutated gene (which would be a billion to one shot anyway) so her offspring wouldn't inherit it. Sheldon would know this - his offspring would carry the mutated gene for superior intelligence, Missy's would not. Anyone knowing enough about genetics to use the term 'randomly mutated gene' understands enough to know that the mutated gene would only be expressed in a direct line from the carrier - Sheldon. Also bear in mind he has a model of the DNA molecule in his living room - it is obviously an interest.
Continuity mistake: In episode 16 of season 1, Penny is talking about making a cake for Leonard's birthday and states she knows his birthday because she was checking a horoscope for him. But in this episode she does not know when his birthday is, which leads to Leonard revealing he was secretly reading Penny's diary. (00:40:00)
Character mistake: Sheldon is wrong about the physics of pushing the furniture up the stairs. This is not just a question of work (energy) but also of power (energy/time). Since he and Leonard cannot produce an unlimited amount of energy per second, they may need to push it slowly, contrary to what he asserts. This is a very serious and very basic error for Sheldon considering he has a PhD in Physics.
Other mistake: When Mary is rubbing VapoRub on Sheldon's chest, she makes a comment that last time she saw that there was no hair, to which Sheldon replies "Yeah it filled in last year." In Season 1, Episode 11, Penny rubs VapoRub on Sheldon's chest and a very clear remark about chest hair was made. Season 1 for the show was 4 years ago.Ashish_Agrawal
Factual error: Sheldon states that the "Reinheitsgebot" would have severely limited the availability of mead in 1487. This is wrong for two reasons, the first being that the most commonly known version of this law wasn't introduced until 1516 and secondly this law only defined the price and the ingredients of beer and had therefore nothing to do with other alcoholic beverages like mead. (00:00:20)Tanngrisnir
Continuity mistake: When Sheldon and Leonard are in the kitchen discussing Leonard's upcoming night out with Mrs. Latham, there's a plastic bottle of orange juice on the table that keeps disappearing and reappearing as the camera switches between Sheldon and Leonard.
Factual error: The foam Sheldon used on Kripke consists of mixing ordinary dish soap, hydrogen peroxide, and saturated potassium iodide. That kind of exothermic reaction is dangerously flammable, so it should have severely burned Kripke and the members of the university board when it fell on them.
Other mistake: In the scene where Leonard threatens to open his production era, we see the Star Trek The Next Generation Geordi LaForge (w/o visor) action figure. The uniform worn by the action figure is only worn by Geordi in Star Trek Generations the movie, not the television series.JetBlazer
Continuity mistake: In "The Luminous Fish Effect" (S1E04) Sheldon tells Penny he weighs 140 pounds. In "The Porkchop Indeterminacy" (S1E16), he tells his sister he weighs 165. 25lbs difference would be a noticeable change, but he looks the same.MFWills
Continuity mistake: Sheldon and Amy are talking while drinking tea together. The entire time, Sheldon has his hand next to his other hand, but in an individual shot, his hand is suddenly on his other wrist.bobthedancingdonut
Factual error: Characters sometimes talk to one another on video calls, and a character (A) often watches these from an angle rather than face on, allowing the viewer to see both character A and the character on the call (B). When this happens, character B is shown turned a little to one side, to give the impression that they are looking directly at character A (as they would be if they were present in the same room). In reality, this means that character B is looking off to one side of their monitor and not at the image of character A, something that it makes no sense to do. No matter what angle the laptop is shown from, provided character B is visible, they should appear to be facing the viewer.paolog
Character mistake: Sheldon says (during Fun With Flags) "But like the flag over Fort Sumter, I'm still here." The Sumter flag was lowered when the fort surrendered to the Confederates. The flag over Fort McHenry was never taken down despite the British bombardment and inspired Francis Scott Key to write the National Anthem about it. Whouldn't a vexologist know that?
Character mistake: While bedridden after his vasectomy, Howard asks Bernadette to grill up a couple steaks instead of picking up Chinese for dinner. She gives him a disapproving look and he says "Kung Pao Chicken, please." A major ingredient of Kung Pao Chicken is peanuts. A major allergy for Howard is peanuts. (00:09:04)
Continuity mistake: In the early episodes, Leonard is depressed and buys cat stuff. He comments that he has taken in to account Sheldon's asthma with a hyper allergenic cat. Later in the series it is Leonard with asthma and Sheldon who gets all the cats.
Character mistake: While driving towards the restaurant, Amy mentions she uses dandruff shampoo for her "dry" scalp. Dandruff and dry scalp have the same main symptoms, which are falling flakes and an itchy scalp, but they are two different conditions. In dry scalp, the skin gets irritated and flakes off. With dandruff, the cause is too much oil on the scalp. That excess oil causes skin cells to build up and then shed. Therefore dandruff shampoo should be used for an oily scalp, not a dry scalp. (00:11:19)