Continuity mistake: After the 'Ramona' conversation between Sheldon and Penny ends, Sheldon leaves Penny alone on the couch. Penny looks up to the "Amy and Penny" painting and says "Don't look at me like that, I tried." In S10 E10, Amy gave the painting back to Penny, which was hung in Leonard's living room.
Factual error: When Raj, Howard and Bernadette are in the car, Raj puts on Batman the Animated Series to distract Howard from his back pain. Howard says "I'm in too much pain to watch cartoo-oh, this is a good one!" However, there is no way he could know that it's a good episode of the show because the opening theme song can be heard playing and the name of the episode does not appear until after it.