The Big Bang Theory

The Desperation Emanation - S4-E5

Leonard: All right. Well, let me see if I can explain your situation using physics. What would you be if you were attached to another object by an inclined plane wrapped helically around an axis?
Sheldon: Screwed.
Leonard: There ya go.

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Super Grover

The Big Bran Hypothesis - S1-E2

Sheldon: Oh Gravity, thou art a heartless bitch.

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The Desperation Emanation - S4-E5

Leonard: What about you, Stuart? You have a girlfriend yet?
Stuart: Oh, yeah. Yeah. I met her at Comic-Con, the one place in the world where saying I own a comic bookstore is an actual pickup line.

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Super Grover

Pilot - S1-E1

Penny: So, what do you guys do for fun around here?
Sheldon: Well, today we tried masturbating for money.

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Pilot - S1-E1

Penny: Four years I lived with him! Four years, I mean that's like as long as high school!
Sheldon: It took you FOUR YEARS to get through high school?

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The Extract Obliteration - S6-E6

Stephen Hawking: Do you like brain teasers?
Sheldon Cooper: Oh, I love brain teasers.
Stephen Hawking: What do Sheldon Cooper and a black hole have in common? They both suck. Neener, neener.

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The Agreement Dissection - S4-E21

Sheldon: You may have gone to Cambridge, but I am an honorary graduate of Starfleet Academy.

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Super Grover

The Bat Jar Conjecture - S1-E13

Sheldon: At this point, I should inform you that I intend to form my own team and destroy the very bonds that bind your very matter together and reduce the resulting particulate chaos to tears!
Leonard: Thanks for the heads up.
Sheldon: You're welcome. [Turns to leave.] One more thing,
Leonard: Yes?
Sheldon: It's on, bitch.

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The Dumpling Paradox - S1-E7

Sheldon: Every Saturday morning since we've lived in this apartment, I have awakened at 6:15, poured myself a bowl of cereal, added a quarter cup of 2% milk, sat on that end of that couch, turned on BBC America and watched Doctor Who.
Leonard: Penny's still sleeping.
[Sheldon stares at Penny for some time.]
Sheldon: Every Saturday since we've lived in this apartment.

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Pilot - S1-E1

Sheldon: We are committing genetic fraud. There's no guarantee that our sperm is going to generate high IQ offspring, think about that. I have a sister with the same basic DNA mix who hostesses at Fuddruckers.

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Sheldon: You participate in the mass cultural delusion that the sun's apparent position relative to arbitrarily defined constellations at the time of your birth somehow effects your personality.

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Sheldon: I'm not crazy. My mother had me tested.

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The Lizard-Spock Expansion - S2-E8

Howard Wolowitz: If it's "creepy" to use the Internet, military satellites, and robot aircraft to find a house full of gorgeous young models so I can drop in on them unexpected, then FINE, I'm "creepy."

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The Vacation Solution - S5-E16

Howard: I'm not signing a pre-nup.
Penny: Alright, Howard Wolowitz, listen up. You sign anything she puts in front of you because you are the luckiest man alive. If you let her go, there is no way you will be able to find anyone else. Speaking on behalf of all women, it is not going to happen, we had a meeting!

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Brad

Pilot - S1-E1

Sheldon: You're not done with her, are you?
Leonard: Our babies will be smart AND beautiful.
Sheldon: Not to mention imaginary.

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The Vegas Renormalization - S2-E21

Sheldon: I'm homesick
Penny: Your home is 20 feet from here!
Sheldon: 20 feet, 20 light years, doesn't matter.

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The Loobenfeld Decay - S1-E10

Sheldon: I was analyzing our lie and I believe we're in danger of Penny seeing through the ruse.
Leonard: How?
Sheldon: Simple: If she were to log on to SoCal physics group.org forward slash activities forward slash other, scroll down to seminars, download the PDF schedule, and look for the seminar on molecular positronium, well then, bippity boppity boo, our pants are metaphorically on fire!

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The White Asparagus Triangulation - S2-E9

[Sheldon points to a computer.]
Sheldon: Tell me what you see here.
Leonard: The blunt instrument that will be the focus of my murder trial?

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The Zazzy Substitution - S4-E3

Sheldon: May I point out that for eight long months, I suffered in silence as your female companion filled our apartment with her off key country music caterwauling, the unappetizing spectacle of grinding a pommel stone against her calloused feet in our living room, and night after night of uninformative TV documentaries about the Jersey Shore.
Leonard: Suffered in silence?
Sheldon: Yes, and I would expect you to do the same.
Leonard: Really? SILENCE!?

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Sheldon: At my age, do you know how I'm most likely to die?
Leonard: At the hands of your roommate?
Sheldon: An accident.
Leonard: That's how I'm gonna make it look.

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Mistakes

When Howard is almost done moving out of his mother's house, there is a table in front of him with a measuring device in the top corner. In one shot, the device moves to the opposite corner of the table. In a few shots later, the item returns to its original position.

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Trivia

In this episode, Sheldon and Amy are trying to decide on couples' themed Halloween costumes. Sheldon is standing in front of the dry erase board. There are 2 columns written on the board. One named "Couples I Like" and the other "Couples You Like." Under the "Couples You Like" column, one of the couples is Blossom and Joey. Blossom is the name of the television character played by Mayim Bialik in the 90s and Joey was one of her brothers.

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