The Big Bran Hypothesis - S1-E2
Sheldon: Oh Gravity, thou art a heartless bitch.
The Bat Jar Conjecture - S1-E13
Sheldon: At this point, I should inform you that I intend to form my own team and destroy the very bonds that bind your very matter together and reduce the resulting particulate chaos to tears!
Leonard: Thanks for the heads up.
Sheldon: You're welcome. [Turns to leave.] One more thing,
Leonard: Yes?
Sheldon: It's on, bitch.
Sheldon: Every Saturday morning since we've lived in this apartment, I have awakened at 6:15, poured myself a bowl of cereal, added a quarter cup of 2% milk, sat on that end of that couch, turned on BBC America and watched Doctor Who.
Leonard: Penny's still sleeping.
[Sheldon stares at Penny for some time.]
Sheldon: Every Saturday since we've lived in this apartment.
Sheldon: I was analyzing our lie and I believe we're in danger of Penny seeing through the ruse.
Leonard: How?
Sheldon: Simple: If she were to log on to SoCal physics group.org forward slash activities forward slash other, scroll down to seminars, download the PDF schedule, and look for the seminar on molecular positronium, well then, bippity boppity boo, our pants are metaphorically on fire!
Penny: Sheldon, have you any idea what time it is?
Sheldon Cooper: Of course I do. My watch is linked to the atomic clock in Boulder, Colorado. It's accurate to one-tenth of a second. But as I'm saying this, it occurs to me that you may have again been asking a rhetorical question.
The Fuzzy Boots Corollary - S1-E3
Raj: Tonight I spice my mead with goblin blood.
The Luminous Fish Effect - S1-E4
Sheldon: Pleased to meet you, Dr. Gablehauser. How fortunate is it that the university has chosen to hire you, despite the fact that you've done no original research in 25 years and instead have written a series of popular books that reduce the great concept of science to a series of anecdotes, each one dumbed down to accommodate the duration of the average bowel movement. Mahalo.
Leonard: I already lied. Why cover it up with another lie?
Sheldon Cooper: Because your lie was painfully transparent, whereas my lie is exquisitely convoluted. While you were sleeping, I was busy weaving an un-unravelable web.
Suggested correction: Genes can be dormant. Which allows them to skip generations. Therefor Missy's children could actually get the "mutated" gene. This is especially true since Sheldon and Missy are twins. Also, since the episode is about who out of Leonard, Howard or Raj, Sheldon would allow to "mate" with his sister, there is the added "insurance" of getting any smart genes from any of the 3 Lothario's mentioned above.
If you are going to try to argue with a geneticist about genetics, please use the correct terms. Sheldon is not referring to a recessive gene - there is no such thing as a dormant gene - he is speaking of a randomly mutated gene. Those are the words he used. If he had inherited a homozygous recessive karotype - one recessive gene from each of his parents - then somewhere in his family tree there would similarly gifted people, in which case he would use the correct term - a recessive gene. If Missy is a heterozygotic dominant karotype possessing the recessive gene for super-genius and the dominant for ordinary intelligence then mating her with Howard, Raj or Leonard would be a waste of time as their dominant genius gene would prevent the recessive super-genius gene from being expressed in the phenotype of the resulting child. The child would be highly intelligent but not on Sheldon's standards. It doesn't matter if Sheldon does not know any of this as he refers several times to a randomly mutated gene, not a recessive one. Missy does not carry the super-genius gene. The posting is correct.
Sheldon is prone to magical thinking when necessary to preserve his obsessive need to control his environment. He may have simply ignored the flaw in his reasoning, as even the most intelligent humans do when venturing outside their ares of expertise. He may be interested in the science of genetics, but his Ph.D. in physics doesn't qualify him as an expert in that field.