Factual error: There is not a snowball's chance of Howard becoming an astronaut. He suffers from cardiac arrhythmia, something about which he is completely open. "Transient" or not this is easily detectable by a simple electrocardiogram, which is a fundamental part of the many medical examinations a potential astronaut will have to pass. He wouldn't even be allowed to start basic training. Note also that during his basic training he shows signs of severe stress and trauma which would inevitably trigger a cardiac episode. Even if it didn't the fact that he was falling apart at the seams would have him removed from the programme for his own good.
Character mistake: In his conversation with Missy Sheldon makes it clear that his superior intelligence is a result of a random, mutated gene. Since Missy isn't similarly intelligent she obviously isn't carrying this mutated gene (which would be a billion to one shot anyway) so her offspring wouldn't inherit it. Sheldon would know this - his offspring would carry the mutated gene for superior intelligence, Missy's would not. Anyone knowing enough about genetics to use the term 'randomly mutated gene' understands enough to know that the mutated gene would only be expressed in a direct line from the carrier - Sheldon. Also bear in mind he has a model of the DNA molecule in his living room - it is obviously an interest.
Plot hole: In Series 1, Episode 7, "The Dumpling Paradox, " Sheldon makes an oblique reference to his financial status: "Frankly, if I could afford the rent, I'd ask you [Leonard] to leave, " meaning he cannot pay the rent on his two bedroom apartment by himself - not that he doesn't want to, he can't. However, in "The Execlsior Acquisition, " we find that he does not even cash his pay cheques. He doesn't even deposit them into a bank account - he leaves them in a drawer in his desk. In Series 2 Episode 14 "The Financial Permeability", he lends Penny a large amount of money from a huge bankroll he just happens to have lying about - again, without cashing his pay cheques! He is obviously independently wealthy. Either he doesn't have enough money to afford the rent or he has enough to work without being paid while practically giving large amounts of cash away. Can't be both.
Trivia: In this episode, Sheldon and Amy are trying to decide on couples' themed Halloween costumes. Sheldon is standing in front of the dry erase board. There are 2 columns written on the board. One named "Couples I Like" and the other "Couples You Like." Under the "Couples You Like" column, one of the couples is Blossom and Joey. Blossom is the name of the television character played by Mayim Bialik in the 90s and Joey was one of her brothers.
Trivia: In the beginning, after talking about the Spider-Man theme, Sheldon says it's right up there after Inspector Gadget and Teenage Mutant Ninja Turtles (to which the gang chimes in "heroes in a half shell, turtle power"). Chuck Lorre, the show's creator, wrote the original TMNT theme song that they are referring to.
Question: Though it comes up in other episodes as well, this one is focused on Sheldon needing a ride everywhere he goes because he can't drive, not to mention his not being welcome on the bus. Of course, this story element would be nonexistent if there was a simple answer, but it does beg the question: Does Pasadena not have taxicabs?
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