Continuity mistake: When Homer drives his car to work it is lime green instead of the usual purplish color.
Revealing mistake: When Moe grabs Ned Flanders' shirt at the bar, Ned's torso is incorrectly drawn over his arms as well as the mug he is holding. (00:10:50)
Answer: I'm not sure if this is the one you're thinking of, but an episode of "Ray Bradbury Theatre," called "A Sound of Thunder," dealt with a similar matter: a group of hunters travel back in time to hunt dinosaurs, only to find things have changed when they get back because someone stepped on a butterfly.
Xofer