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Trivia: Jared Leto asked to wear opaque contact lenses in order to play the blind Niander Wallace. He wanted to lose his ability to see to get into character.

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Trivia: During the scene that reveals Kirby is still alive via YouTube link, if you look very closely, you can also see a link to a YouTube conspiracy video called "Did the Real-Life Stu Macher survive?" This is an easter-egg referencing a popular fan-theory that Stu actually survived the original film and would return as the killer in a future installment.

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Trivia: Some theaters had a bonus scene that appeared right before the film started in which Ghostface (voiced by Roger L. Jackson) appears onscreen and essentially hints that he will murder anyone who gives away any spoilers.

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Trivia: When Dewey is watching Gale on the news, you can just barely hear a joke Gale makes about not wanting to have bangs ever again. This is a reference to Gale's unfortunate hairstyle in "Scream 3," which features some truly horrendous looking bangs. The look became something of a joke and later a meme, so the line was added as a subtle joke.

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Trivia: Neve Campbell almost didn't return because she didn't want to make a "Scream" movie without Wes Craven at the helm. What persuaded her was a letter she received from the new directors, explaining their passion, admiration and respect for Craven's work. The letter quickly won her over and she joined the film soon after.

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Trivia: When the dedication to Wes Craven appears at the start of the credits, you can faintly hear the sound of birds chirping. Craven was quite well-known for being an avid birdwatcher, and also fought to protect endangered species of birds. He even helped get legislation passed to ban the use of lead ammunition, which can fragment on impact and harm birds and other wildlife if accidentally ingested. The sound of birds was added as a tribute to his passion.

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Trivia: It is briefly mentioned that Sidney Prescott's former home is located on "Elm Street." This is a reference to the film "A Nightmare on Elm Street," which was directed by original "Scream" director Wes Craven. (Supposedly it was going to be mentioned in the original "Scream" as well, but the reference was cut for whatever reason).

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Trivia: SPOILERS: In the climax, Amber is soaked in hand sanitizer and set in fire. Amber's actress Mikey Madison had previously appeared in Quentin Tarantino's "Once Upon a Time in Hollywood" which came out less than three years prior... where her character is similar killed by being set on fire. (Albeit with a flamethrower.) Given Madison is only 22 and has only appeared in six live-action feature films... that's actually a pretty interesting (and darkly funny) coincidence.

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Trivia: If you look closely, you can see a box containing Tatum Riley's ashes on a shelf in Dewey's home. Tatum was of course Dewey's sister who was killed in the original movie.

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Trivia: The song "Red Right Hand" briefly plays during one of the murder scenes. The song has been featured in every other "Scream" movie except "Scream 4." (They wanted to include the song in the fourth film, but there was a copyright dispute behind the scenes and it could not be included).

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Trivia: Sidney makes a brief passing reference to having a husband named "Mark." After hearing much fan speculation, the directors confirmed that her husband is indeed Mark Kincaid from "Scream 3," who was played by Patrick Dempsey.

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Trivia: The demon effects were done by Carlo Rambaldi, who is arguably most famous for creating the design of the benevolent titular character from Steven Spielberg's "E.T."

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Trivia: The exterior of the house was actually shot at the Winchester Mansion. (Albeit not at the main entrance.) The Winchester Mansion was owned and built by Sarah Winchester, who was convinced that she was being haunted by the ghosts of those that were killed by the Winchester rifles her family had created. Throughout her life, she had more and more construction done on the house, often creating stairways and doors leading to nowhere, to try to "trick" the ghosts and keep them from getting her.

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Trivia: The machine is called "Sissy," which is short for "Sisyphus." In Greek mythology, Sisyphus was cursed to push a boulder uphill for eternity - every time he'd reach the top, it would roll back down and he'd have to start again. The use of the name "Sisyphus/Sissy" is a reference to the fact that Tree has to relive the same day over and over again, much like Sisyphus must push the rock up the hill over and over again.

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Trivia: The costume designer threw in Easter-Eggs that most people never notice. When Tree wakes up in the other dimension, she's wearing the same clothes from the first movie, including a concert-tee. However, if you compare the shirts from the two movies, while the picture is the same, the words are slightly different. (Ex. A different venue is listed on the shirt.) This is to provide a subtle hint Tree is in another dimension. There are similar tiny changes in the other character's clothing, too.

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Trivia: Just a funny bit of censorship to look for. In the film, Tree wears a shirt that says "FML" in one scene. For those who don't know, this is an abbreviation for the phrase "F**k my life," which is a phrase commonly used to express frustration when something bad happens. But because of its profane connotations, the shirt was digitally altered in trailers to instead say "OMG," which means the much less naughty "Oh my god."

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Trivia: There was a deleted scene explaining that the grown-up boys from the prologue (who beat up Jeremy at the dance) were found dead shortly before the events of the film, implying that they were also murdered, but it was cut for whatever reason. Ironically, this would have solved one of the major complaints audiences had with the film, which is that Jeremy is going after the girls who rejected him instead of the boys who bullied him - he was actually meant to be going after ALL of them.

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Trivia: As of 2022, this is the only widely-released theatrical film to feature David Boreanaz in a starring role. His only other starring film roles have been in TV-movies, limited releases and direct-to-video movies. (Although thankfully, he is an incredibly successful television actor).

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Trivia: Supposedly, one early draft of the script had Rick and Evie resurrecting Imhotep from the first two films as a begrudging ally to help them defeat the Dragon Emperor. Imhotep actor Arnold Vosloo wasn't keen on this idea, and opted out. He was also good friends with Stephen Sommers, who directed the first two films, and didn't want to do a "Mummy" movie without him at the helm. (Sommers produced this film but stepped away from the director's seat).

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Trivia: The actors who voiced the toons would usually stand off-camera and recite their lines to help the live-action actors with their performances. Charles Fleischer, who voiced Roger Rabbit, had one peculiar demand, though - he asked the production to make him a full-size Roger costume to wear, complete with fur and big, floppy ears. He felt that dressing up in a (ridiculous and hilarious looking) Roger costume would help him get into character every day.

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