Continuity mistake: When Spock races back into the phaser control room, he places his electronic tablet on the console and kneels to check on the unconscious Styles and Tomlinson. From one shot to the next, the tablet changes its position on the console behind him.
Character mistake: Spock tells Kirk that without being able to test their vaccine with the ship's computers, "it could be a beaker of death." The vessel that the vaccine is contained in is a flask, not a beaker. The ship's science officer should know the difference.
Other mistake: On some VHS editions of this episode, the back cover features a picture of what appears to be both good and evil Kirk sitting at a table, however this never happens anywhere in the episode. That picture is actually from the episode "What Are Little Girls Made Of?"