Continuity mistake: When Brian stops at the Marriott, he orders a Jack on the rocks. As he is ordering it, there is a woman in the background with a martini, then when the camera cuts to behind the counter when Brian receives the Jack on the rocks, the same woman has red wine instead of a martini.
Continuity mistake: When Stewie goes down the stairs in his bed, when he hits the front door, the door opens outwards outside. It always opens towards the inside. Plus in this episode, the door is brown when he rolls outside. Next scene and the other times in the show it's a red door.
Continuity mistake: Chris puts a video recorder in his room to try to capture the angry monkey in his closet to show Peter and Lois. He views the tape the next day and sees Peter and Quagmire enter his room. Quagmire punches Chris in the eye and bruises, it but when we see Chris the very next day, there's no black eye.
Continuity mistake: In this episode, Lois is shown to have dated Naomi during college. In the episode "Meet the Quagmires", it was established that Lois and Peter were already dating when Lois was eighteen. She accepted Peter's marriage proposal at that age. She would have been engaged and possibly married during college.