Continuity mistake: When Blade gets his serum, Whistler holds his hand, then they see the girl run. In one shot, Whistler goes right, leaving the suffering Blade. In the next shot (close up on Blade), you can see that Whistler is still holding Blade's hand. (00:26:57)
When Blade's mother was bitten by a vampire during pregnancy, she did not know that she gave her son a special gift while dying: All the good vampire attributes in combination with the best human skills. Blade grew up to be a vampire hunter for revenge on his mother's death. The vampires, who managed to infiltrate nearly every major organization, need Blade's very special blood to summon La Magra, the blood god, in order to reign over the human cattle, as they call us.
Karen: Why do you hunt them?
Whistler: I had a family once. A wife and two daughters. Then a drifter came calling one evening. A vampire. He toyed with them at first. Tried to make me decide which order they'd die in.
Trivia: During the chase with officer Krieger, the vampire on the side of the road biting the girl's neck is actually director Stephen Norrington. (00:40:15)
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