Blade's mother is still alive, and Deacon Frost is the one that bit her. Frost turns into a Blood God. Blade kills his mother and regains his strength by sucking blood from Karen and uses the blue serum to destroy Frost. The film ends with Blade in Russia.
Blade: You better wake up. The world you live in is just a sugar coated topping. There is another world beneath it. The real world. And if you want to survive it, you better learn to pull the trigger.
Trivia: In the Marvel Comic series where the characters originate from, Deacon Frost was actually an elder man, and an alchemist who dabbled in vampirism and - via one of his experiments - turned himself into a unique vampire who could create doppelgangers of his victims.
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