Continuity mistake: When Brant kills Barry at the end of the movie, Brant lowers his gun after shooting him, but in the next shot he is pointing his gun at Barry. Also, the scene shows Brant holding a semi-automatic style handgun before shooting Barry, then when the scene pulls out it shows him holding a revolver, then shows him holding the semi-auto again.
Plot hole: If Bradley Cooper was able to "quintuple" his money every day in the market as he claims to have done, he would have been able to earn the $100k he borrowed from a loan shark within a few days, starting from $800. Alternatively, he is shown in one scene winning a pot in poker where he could presumably also make a large amount of "seed" money from gambling. There was no need to borrow such a small sum of money from a loan shark, making the entire sub-plot unnecessary.
Other mistake: In the pre-credit scenes when the chopper spots the runaway car, Driver guns it (he clenches his jaw, fists and you hear the engine revving and gears changing) but he never catches up with the two cars only a few feet in front of him (which are proceeding at normal speed) for the whole length of the bridge.
Plot hole: Through this film (and its predecessor) it is established that the creature imitates its victims perfectly, having all of their knowledge and memory. At the end, when the female lead tells the male lead she knew he was human because of his earring, he reaches for the wrong ear, confirming he is The Thing. Even if The Thing couldn't reproduce the earring, it would have known which ear it was supposed to be in.
Suggested correction: It is also established in this film that the creature cannot perfectly imitate inorganic materials; the tooth fillings, metal plate, etc. Kate knows that Carter is The Thing and asks him a trick question about his earring to confirm it. The fact that The Thing reaches for the wrong ear means that it didn't know where the earring really was because it cannot perfectly imitate inorganic materials. There is no mistake here.
Revealing mistake: While Bishop and Steve McKenna are practicing with various firearms, a slow-motion shot in the film of Steve shooting a .50 caliber rifle shows that, while the sequence depicts him firing "live" rounds, the extracted shell casing is from a "Blank" cartridge (evidenced by the crimped forward portion of the brass casing). (00:34:15)
Factual error: When Cattleya escapes through the sewer drain and winds up in front of the U.S. Embassy, she uncovers the manhole all by herself. Impossible for such a young child to do.
Revealing mistake: In the final shot of the film, Jill's head moves slightly when she's supposed to be dead.
Continuity mistake: Before killing the dragon, Baby Doll is holding her sword with her right hand. But when she jumps up and kills the dragon she is suddenly holding it with her left hand.
Factual error: Erik arrives in Argentina at a place called Villa Gesell, shown to be a town in middle of mountains. Villa Gesell is a beach town on the Atlantic Ocean coast, with no mountains.
Factual error: When the action moves to England after the failed award ceremony, the British Union Flag hanging from the wall is upside down. The broad white band should be at the top left (nearest the top of the flag pole).
Plot hole: No one wonders what happened to all the staff and patients at that sanatorium? No police ever came there and checked the place out after 30 years? And all the patient records, furniture, etc are still there?
Audio problem: This scene is repeated multiple times in the movie: usually when the main character enters the "source code" the scene begins by panning over a small pond showing a Canada goose taking flight. However the sound editor makes the mistake of dubbing in a recording of a hen mallard duck.
Factual error: When a global map is shown, the location of Toronto is incorrect. What is labelled as Toronto is actually the location of Montreal. (01:08:05)
Continuity mistake: After meeting Elise on the bus and getting his Blackberry dumped into his coffee David Norris calls his friend Charlie with his "spare phone" (silver). But after a cut or two you can see that he uses his BlackBerry again. So he has changed the phone during the conversation AND his coffee BlackBerry seems to be working again. (00:19:20 - 00:20:10)
Continuity mistake: When John sees his photos on Sarah's website, the lower row of photos shows him throwing a football. However, when Sarah took those photos earlier, she only took out her camera AFTER he threw the football, while John was already talking to Sam.
Revealing mistake: At the start, just as Moreau rides up the stone road leading to the monastery up ahead, before he passes the two guards we can see that it's a flipped shot - note the backwards license plate number.
Continuity mistake: In the scene when Danny and Hunter try to escape, Hunter grabs his wrist watch back from an enemy and drops it in his left pocket. He has no watch on his either of his wrists, yet in the next shot, his watch suddenly appears on his left wrist. (00:14:55)
Factual error: When Nate dies by the alien moon rocks, his helmet visor "explodes." The visor in the film shatters like glass, but the real visors on actual spacesuits are made of polycarbonate, a plastic that does not shatter but deforms.
Factual error: In the scene straight after the opening credits we are taken to Baker Street where construction work is being done. This work is identified by a sign with a logo as being for the underground line. The logo type face was developed by a Mr. Edward Johnston for London Underground from 1913 but the distinctive typeface used in the film was not in place until 1919. This is obviously long after the 1891 setting of the film.
Factual error: When Amber Heard dives out of the caravan onto Nicolas Cage's car, the bad guy fires his 6 shot revolver at her at least 9 times.
Suggested correction: The main character says he did quintuple his money four days in a row, not that he could continue to do so. "Presumably" he could do anything, like robbing a bank. Gambling is not a secure source of income, even with knowledge of the odds and every tell, he could also lose a lot of money.