Character mistake: In his argument with Leonard regarding Superman's ability to fly, Sheldon states that in Superman 1, Lois Lane is two feet off the ground when Superman catches her as she falls from the helicopter. Not so. Superman catches Lois at least ten stories up. Additionally, both Penny and Sheldon say Superman "swoops down" to save Lois. Penny can be forgiven, but Sheldon would know better: Superman flies UP from ground level to catch Lois.
Character mistake: In his conversation with Missy Sheldon makes it clear that his superior intelligence is a result of a random, mutated gene. Since Missy isn't similarly intelligent she obviously isn't carrying this mutated gene (which would be a billion to one shot anyway) so her offspring wouldn't inherit it. Sheldon would know this - his offspring would carry the mutated gene for superior intelligence, Missy's would not. Anyone knowing enough about genetics to use the term 'randomly mutated gene' understands enough to know that the mutated gene would only be expressed in a direct line from the carrier - Sheldon. Also bear in mind he has a model of the DNA molecule in his living room - it is obviously an interest.
Character mistake: When Sheldon arrives at the apartment with his Nintendo 64 in the box, he tells Leonard that they can play Super Mario 64. He then proceeds to say, upon finding a memory card, that they can pick up where he left off. Super Mario 64 does not make use of the memory card for progression, all of that data was saved on the cartridge.
Character mistake: Being the first to play in the "time machine," Leonard says he will set the date for March 10, 1876. Howard says "Good choice. Alexander Graham Bell invents the telephone and calls out for Doctor Watson." Bell's assistant, Thomas A. Watson, was an experienced electrical designer and mechanic, but he did not hold an advanced degree. It is well documented that the first words transmitted over the telephone identified him as Mister Watson.
Character mistake: When Howard finds the stack of paychecks in Sheldon's drawer and wonders why Sheldon hasn't cashed them, Sheldon explains that he's saving them to purchase items that have yet to be invented and he doesn't trust banks. But just keeping them in his drawer doesn't do anything, because checks are voided after a set period of time and they would eventually become worthless.
Add timeCubs Fan
Character mistake: When Penny says she smells Chinese food and Sheldon corrects her by telling her she's slipping because it's Thai, Sheldon is eating the food with chopsticks, even though in a previous episode he uses a fork and spoon because that's how Thai people eat their food.
Character mistake: Sheldon is wrong about the physics of pushing the furniture up the stairs. This is not just a question of work (energy) but also of power (energy/time). Since he and Leonard cannot produce an unlimited amount of energy per second, they may need to push it slowly, contrary to what he asserts. This is a very serious and very basic error for Sheldon considering he has a PhD in Physics.
Character mistake: When speaking on the radio, Leonard says he has never heard himself through headphones. We have seen him several time wearing headphones while speaking, for example during a podcast with Will Wheaten and on Science Friday too.
Character mistake: When Howard says they should put the time machine into the elevator in 1-14 "The Nerdvana Annihilation", Leonard states the elevator had been broken for two years, but in this episode, we found out the elevator broke seven years earlier.
Character mistake: Sheldon refers to using the spray bottle as negative reinforcement when it is in fact positive punishment. Reinforcement involves encouraging a behaviour by either adding or removing a stimulus whereas punishment involves discouraging a behaviour by adding or removing a stimulus. Sheldon would know the difference.
Character mistake: When Sheldon is placing his order near the beginning of the episode, he states "In the mid-18th century, King Rama IV of Siam..." King Rama IV was born 18th October 1804 and died 1st October 1868. His reign was during the mid-19th century (1851-1868).
Character mistake: In Amy's lab, when she is complaining to Sheldon how she gave him the simplest tasks, and that they're still not done, Sheldon replies with how Einstein failed math because he wasn't challenged, and that it is the same case with him. Einstein never failed math. Sheldon of all characters should know that.
Character mistake: The bird that Sheldon is afraid of is referred to in the scene as a "Blue Jay." In fact, the bird is a Black-throated Magpie. A Blue Jay is a little smaller, has a shorter tail, does not have the darker plumage, and can be quite obnoxiously vocal.
Character mistake: When working in the Cheesecake Factory, Sheldon says "Bonne appétite," with a hard T at the end. He should know that this is incorrect and would be the first to remind others that the correct phrase is "Bon appétit" (pronounced "appéti" - it is masculine and the t at the end is not pronounced).
Character mistake: When Leonard and Sheldon sit down for lunch at work, Sheldon grabs the salt and pepper and begins to shake the "shakers" over his food. However, these are grinders and not shakers. He would have had to twist the tops in order to get any salt or pepper.
Character mistake: As they drive to Todd Zarnecki's to confront him, Sheldon says, "I almost feel sorry for the poor fool, sitting in his split-level suburban ranch..." Architecturally, split-level (technically three levels joined by half flights of stairs) and ranch (single level) are separate and distinct designs. There is no "fusion" of the two. I can't help but think Sheldon would have corrected anyone who said the same thing.
Character mistake: Even with Penny and Zack the guys are one man short to be the original JLA because they they don't have the Martian Manhunter. If they used the same costumes in the previous year, they would have been three people short of the original line-up.