Continuity mistake: The man conducting the tour of the box factory tells the children that they will not be able to see a finished box, as the boxes are assembled in a separate location. However, moments earlier we saw a flat box going through a machine, and coming out finished.
Continuity mistake: When Homer is shouting at Skinner about losing Bart, if you look closely you can see that the box with the red cap goes past Homer. However, when he turns round and sees that red cap on a box, that box has already gone by.
Continuity mistake: After Bart's career is dead, he is at his house, and Marge brings out a box of Bart related items. She pulls out a doll and hands it to Bart, as she is handing it to him, the doll's arms disappear, and then reappear when Bart touches it.
Continuity mistake: When Bart is writing from the books in the kitchen, he is seen writing on the paper. In the next shot of him, the paper is clean.
Continuity mistake: In the opening shot of Apu serving his customers, you can see Martin wearing a purple shirt. However, later when all the customers are grumbling about the price, you can see Martin walk away wearing a white shirt.
Continuity mistake: Apu grabs the ham and crosses out of the expiration date with a thick black marker. When he places the ham on the shelf the black marker cross out is gone and the writing on the pack looks perfectly printed as before.
Revealing mistake: Apu's moustache disappears for some seconds after having his name tag removed.
Continuity mistake: When the robber shoots Apu, he is shot around his leg. In the next shot, the wound is in his chest.
Lisa vs. Malibu Stacy - S5-E14
Continuity mistake: During both conversations Lisa has with the real Stacy (the creator of Malibu Stacy), her drink magically refills itself a number of times.
Lisa vs. Malibu Stacy - S5-E14
Continuity mistake: When Lisa and Marge go on the tour, when the film has finished the woman turns it off with a remote controller and puts it behind her back. In the next shot from behind her it isn't in her hands and there is no sign of a pocket or any indication she put it anywhere else.
Lisa vs. Malibu Stacy - S5-E14
Revealing mistake: When Lisa says "Now all we need is a name", Maggie's head disappears for a split second right before the shot changes to Bart talking.
Lisa vs. Malibu Stacy - S5-E14
Continuity mistake: When the Simpsons are leaving the house to go to the mall. The aerial shot shows that they are leaving in Marge's red station wagon, but the very next shot of them in the car shows that they are in Homer's pink sedan. The shot of the station wagon leaving is probably a re-used shot from a previous episode.
Lisa vs. Malibu Stacy - S5-E14
Continuity mistake: When the Simpsons are about to leave the house to go to the mall, they're all wearing jackets, but when they're in the car just a few seconds later, none of them have their jackets on.
Other mistake: In the scene where the Simpsons are viewing the path of the Corvair's Re-entry, the blip representing the spaceship crosses the entire US from North-West to South-East in about three seconds. This is really impossible, even for something going as fast as a spaceship on re-entry would be.
Continuity mistake: When Homer is in space, when he is about to free the ants, the crisps that he opened earlier have disappeared from the background. This type of mistake happens again when both the crisps and the ants disappear and reappear between shots.
Continuity mistake: When Barney becomes his old self again at the training center, he gets on a jetpack while holding a bottle. In the next shot while he is in the air, the bottle is gone.
Revealing mistake: When Moe grabs Ned Flanders' shirt at the bar, Ned's torso is incorrectly drawn over his arms as well as the mug he is holding. (00:10:50)
Continuity mistake: At the end of the episode in church when the group of parishioners moves forward to forgive Ned there is a woman amongst the group who has light green hair. However, when there is a wide angle shot of the group again she is nowhere to be seen.
Continuity mistake: When Homer drives his car to work it is lime green instead of the usual purplish color.
Other mistake: When somebody throws a cola can at Homer, the can never hits the ground.
Answer: I'm not sure if this is the one you're thinking of, but an episode of "Ray Bradbury Theatre," called "A Sound of Thunder," dealt with a similar matter: a group of hunters travel back in time to hunt dinosaurs, only to find things have changed when they get back because someone stepped on a butterfly.
Xofer