Continuity mistake: In the bit where they sit on the sofa at the start of each episode, there is one rather long one where it starts off with the Simpsons dancing in a line, then gradually evolves into a circus with elephants and men dancing around fire. Look closely in between Homer's right leg and the dancing woman on his right. There is a pile of books on the little shelf underneath the lamp and telephone, and just as the camera starts zooming out from the line of dancing, the orange book on the left noticeably changes to purple. (00:01:20 - 00:00:00)
Continuity mistake: When the flashback of Ned and Todd Flanders singing in the Simpsons' doorway, Homer says he could use a TV tray. Then it goes back to the present time and Homer picks up a beer from the TV tray which is next to the couch. The TV tray was never there at any other point in the show. (00:10:40)
Continuity mistake: After Krusty is done doing the special promotion commercial, he is given a telegram informing him of the Soviet boycott. However, this is a flashback, and at this point in time Krusty is illiterate (as will later be established in season 1) so he shouldn't be able to read the telegram.