Plot hole: It is stated Leo is born on May 6th, 1924. Yet he was in his 20's as Piper's ex-lover in his past life around 1924. It also stated that that is when he died and became a whitelighter but the war wasn't until 1942. He died shortly after that meaning he didn't become a whitelighter until after 1942.
Plot hole: When teenage Prue has run away with the demon, and Phoebe and Piper find her in the park, teenage Prue is 'killed'. Her sisters drive her home to get Leo to heal her, but shouldn't they have just been able to call to Leo to orb to them when Prue was first hurt, and heal her in the park, and save driving back to the Manor and risk Prue dying?
Plot hole: When Gith takes the potion from Chris, he ends up stomping on it and shattering the potion bottle - making contact with the potion. We've seen that potions don't have to be thrown by someone who's even a witch for them to work (like when Cole's powers were stripped etc) so why on earth would he do this? And how did it not vanquish him? There are other ways he could have gotten rid of the potion that didn't involve a way that really should have vanquished him.
Plot hole: Cole explains that the demonic power is driving Karen mad because she is human. Cole later has Paige infected with one to drive her mad. This doesn't make sense since Paige is doubly not human, and shouldn't be driven mad. In fact the Charmed Ones have had demonic powers before and were not driven mad, but instead turned evil.
Plot hole: The innocent who gets Piper's powers uses them to freeze Piper and Phoebe. But even though Piper and Phoebe no longer have their unique powers, they are still good witches; they were still able to scry, and we have encountered good witches on the show in the past who had no powers at all. And by the rules of magic within the show, good witches do not freeze.
Visible crew/equipment: In the scene where Prue comes home and finds Andy inside the manor. There is a shot where if you look behind Andy's shoulder you can see half of the body of the director in the background in the observatory room sitting in a director's chair. (00:16:00)
Continuity mistake: In 3-5 Sight Unseen, we can clearly see Cole turn the air conditioning very cold and open all the windows so that the Prue, Piper and Phoebe can see the invisible demon, and in season 2 when Prue is turned into a man Phoebe asks "did you fix the air conditioning?" But in this episode Phoebe asks Piper why they have never invested in air conditioning.
Plot hole: In episode 1-2 ("I've Got You Under My Skin"), Alec buys Phoebe a martini at Quake. but then in episode 5-11 ("The Importance of Being Phoebe"), Cole tells Kaya that Phoebe doesn't drink. Then, in episode 5-17 ("Lucky Charmed"), Jason buys Phoebe a "Martini, dirty" at the end.
Continuity mistake: After the Grimlock kidnaps the child getting the ball, Prue goes after it. But the demon opens a hole in the earth and jumps through it and it closes. Prue then reaches the spot where the Grimlock disappeared and she is surrounded by dead leaves and trees. Then it goes to another shot of Prue turning around. Suddenly the trees and dead leaves are gone and she is standing in an open area with green grass and no trees.
Plot hole: According to the family tree viewed in this episode, Penny "Grams" Halliwell was born on 6/23/1937, and her daughter Patty, the Charmed Ones' mother, was born on 4/5/1950. In addition, Patty's father was born in 1930. So, according to this, Penny gave birth to her daughter at age 12, while married to a 20 year old man. That's quite outlandish, to say the least. (00:20:05)
Plot hole: In the opening scene, Chris directs Piper and Phoebe on how to vanquish the amorphous demon. He says that it will attack "fast and hard" as soon as it senses Phoebe's magic when she levitates. But Chris had orbed out of the warehouse and back in, and the demon didn't react to the magic. Later in the episode, it is specifically attracted to a use of orbing, several times.
Character mistake: Katya (as Nina) says that Pandora's Box is "a gift the gods gave to Prometheus." But the Box was given to Epimetheus, not Prometheus. Epimetheus ignored the warnings of Prometheus, his brother, and accepted Pandora herself, who bore a box, as a gift from the gods.
Continuity mistake: In the previous episode, Piper tried out for a job as a chef at a restaurant called "L'Opera Ristorante" and was hired by Chef Moore. Then in this episode, she works at a bar and restaurant called "Quake," but she talks about Chef Moore quitting and leaving her in charge of the establishment, so it's not meant to be a different place.