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Continuity mistake: When Lee sits down to copy the files from Cyrex, the wide shot shows the clock as 10:25, a few seconds later Lee checks her watch then looks at the clock on the wall which then changes to 10:26 but then after she is done making the second copy the clock on the wall is back to 10:25 again. (00:16:25)

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Plot hole: When the doctors are discussing the condition of Bowman's mother, a newspaper headline on the wall displays the pictures of both Bowman and Frank Poole. These pictures are actually still shots of the two actors from an earlier conversation they had with HAL in the previous film. Since Discovery has been dormant for nine years, how did Earth manage to use these particular shots for the newspaper?

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Character mistake: During the "heart attack prank" just before the paramedics get to Frank, Eastwood mistakenly opens his eye before the paramedics wake him.

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Trivia: When "Bowman" visits his widow via television at her apartment, she's just finished watching a commercial for Pan-Am. The commercial is actually stock footage of Heywood Floyd's shuttle flight to the rotating space station in the first film, 2001.

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Plot hole: When the cop shows Pam the newspaper clippings they include what look to be fresh photos of the real Jason from the events of Part IV, yet no photographer is ever seen taking pictures of Jason alive in the previous films and most likely wouldn't live long enough to publish the photo. (01:25:00)

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Trivia: Not long after Eddie Murphy and Arsenio Hall arrive in Queens, a "Wonder Bread" truck can be seen passing by in the background. Eddie Murphy previously recalled his experiences as a child eating Wonder Bread during his famous stand-up film "Eddie Murphy: Raw" the previous year.

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Plot hole: It would seem to go against Secret Service procedure (as well as National Security) for an agent like Frank to give such an openly candid interview to a magazine such as Esquire.

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