Continuity mistake: When the police car rolls out of the car wash, both passenger and driver's doors are open. When the shot changes to the deputy holding the rifle, the driver's door is closed. In the next shot both doors are open again.
Continuity mistake: At the end, during the fighting in the Cathedral, the last woman left is getting first cut by Steven Seagal at the right breast. A moment later, her cut is on her left side. The next moment it is on the right side again.
Factual error: The actual Tsavo lions responsible for the killings had no manes - see for yourself; they are on display at the Field Museum in Chicago. [The filmmakers employed artistic license in using maned lions. They were also certain to include - at the very end of the movie - footage of the real Tsavo man eaters, as they appear in the Field Museum.]
Continuity mistake: In the scene where Eddie Murphy is going into the crypt, he takes one of the lit torches. While they are trying to escape the skeletons, the door to the crypt closes and locks. When they show the shot of his son outside, you see two torches again. When he gets the doors open and they leave, you see one.
Revealing mistake: Mac and Dillon go after the Predator. The Predator is sitting in a tree, and Mac points him out to Dillon. They both agree that they see it and take position. Mac crawls underneath the alien and is killed by his laser. The Predator then sees Dillon and lasers his arm off. Dillon's arm falls to the ground with the gun firing. Quickly Dillon turns and reaches for the machine gun around his neck. When he turns you clearly see his bloody right stump and his right arm sticking out the bottom of his jacket. [Note: As far as I can work out, this has been cunningly edited out of the UK DVD version].
Other mistake: Towards the end of the film, after Snipes beats up of a lot of vampires, Whistler throws Blade's sunglasses to him. They show him throw them in one shot, then in the next shot they show Snipes catching them. But look in the background at Whistler, he doesn't have the glasses, but is moving his arm like he is throwing them. The glasses must have been computer animated, and bad editing contributed to this mistake. (01:37:34)
Visible crew/equipment: When Francesco and 'she' are in the cemetery together and the little blue flame-beings gather around to watch them, you can see the wires they're suspended on several times. This is most apparent when Francesco sees the first one (moments before seeing 'she' at the fountain) and also just before they are all frightened away. (00:17:30 - 00:20:40)
Audio problem: A soda can that is supposed to be full hits the man. When the can hits the ground you can hear that it's empty.
Continuity mistake: When Frankie is about to receive the first stigmata (when sitting in the bath), a pigeon suddenly flies up. When she takes a piece of a feather that flew into the water, you can already see stigmata marks on her right-hand wrists.
Other mistake: When they encounter the first ant, the policeman runs out of ammo, but the FBI agent fires at least nine shots. Not bad for a snubnose revolver that holds 5 or 6 rounds.
Continuity mistake: When Scott gets his throat cut, blood pours out. Yet when Terri spins him around, there's no blood anywhere on him except a small amount on his shirt sleeves.