The Higgs Boson Observation - S6-E3
Continuity mistake: Sheldon is taking composition books out of a box that was sent to him. When he first starts pulling them out, he has two composition book in one hand. Two shots later, he has only one composition book in his hand, but he is picking up a second one.
The Countdown Reflection - S5-E24
Continuity mistake: Near the beginning of the episode, Howard said the launch was on the Friday before his planned wedding. They decide to marry before he launches, and they say they only have two days. Then he tells the clerk at City Hall that he launches on that Sunday. Too many inconsistencies.
The Consummation Deviation - S12-E8
Continuity mistake: Leonard tells Raj that the first sex between Penny and Leonard was fantastic. But episode S3E2 is all about how bad it was.
The Imitation Perturbation - S12-E6
Continuity mistake: When Bernadette and Amy are sitting in the kitchen, the teabag in Bernadette's cup changes position between shots.
The Big Bran Hypothesis - S1-E2
Continuity mistake: When shifting the box along the floor of the 3rd floor landing, Leonard's grips on the box is constantly changing. (00:06:00)
The Cushion Saturation - S2-E16
Continuity mistake: When Howard and Leslie are in the paintball shed, Howard's paintball ammo pack is closed, but when he and Leslie start kissing, it's open.
The Precious Fragmentation - S3-E17
Continuity mistake: At the cheesecake factory, the necklace is wrapped around his middle and ring fingers, then in the next shot, he is just holding it. (00:08:00)
The Hofstadter Isotope - S2-E20
Continuity mistake: Near the end of a conversation with Stewart, Penny is holding a drawing that Stewart drew for her. In the next shot, it is now on the counter and she is picking it up.
The Hawking Excitation - S5-E21
Continuity mistake: When Howard and Bernadette are in his bedroom, there is a bottle of Vitamin Water to Howard's left. In one of the shots, the bottle has completely vanished out of frame, but returns in the next shot.
The Hawking Excitation - S5-E21
Continuity mistake: Penny is talking to Sheldon in the laundry room and places a box of detergent on the machine. The side of the box is facing her. In the next shot, the box has turned to face her.
The Russian Rocket Reaction - S5-E5
Continuity mistake: In the scene where Howard and Bernadette are about to have sex and Bernadette leaves to "brush her teeth", Howard stretches and lays on the bed uncovered. After Howard's mother yells "over my dead body my son goes to space" and Bernadette appears again and says "I'm ready", then it flashes back to Howard and he is instantly covered up.
The Precious Fragmentation - S3-E17
Continuity mistake: When Sheldon sneaks into Leonard's bedroom while Leonard and Penny are sleeping, Penny has her arms out over the blanket and Leonard has his on his pillow in front of his face. When Sheldon leans over Penny only her hands are on top of the covers and Leonard's are tucked under his pillow.
Continuity mistake: When Penny is talking to Leonard about who read her Ex's blog, she has a spoon full of ice-cream. Camera cuts and it's now empty. (00:05:00)
The Prestidigitation Approximation - S4-E18
Continuity mistake: It is well-known that Leonard's glasses do not have lenses to avoid catching reflection by the lights. In this episode, Priya takes Leonard's glasses off, and they have lenses.
The Extract Obliteration - S6-E6
Continuity mistake: Sheldon is siting at the kitchen counter with a mug in front of him. In one shot, the string of a teabag appears coming out of the mug. In between shots, the teabag string moves by itself.
The Robotic Manipulation - S4-E1
Continuity mistake: At the start, as Howard says "And finally my kung pow chicken" the robot arm is level with the top of the bag. Camera cuts and it's reaching to the bottom of the bag. (00:00:15)
The Classified Materials Turbulence - S2-E22
Continuity mistake: Leonard is talking to Stuart at the door to his (Leonard's) apartment. Howard then comes over and slams the door in Stuart's face and Leonard has moved back about 4-ft instantly.
The Lizard-Spock Expansion - S2-E8
Continuity mistake: The way Leonard holds the can of Diet coke before he puts it down changes between shots. (00:00:25)
The Matrimonial Momentum - S9-E1
Continuity mistake: In the first half of the episode while in Las Vegas, Penny's hair is short; however, later in the episode when she is back in the apartment speaking with Sheldon, her hair is much longer, albeit tied back in a bun, but very obviously much longer and a very different color. The scene from Las Vegas to her apartment was less than 24 hours apart and would have been impossible for her hair to have grown so much.
The Hot Troll Deviation - S4-E4
Continuity mistake: When Sheldon and Raj are arguing about having a desk in Sheldon's office, Sheldon's bottle of water keeps rotating without anyone touching it - take note of the label. The level of water in Sheldon's drink also keeps changing between shots. (00:06:20)
Chosen answer: It does. The variable cleanliness of the cab and the habit of taxi drivers to engage customers in small talk would be too much for Sheldon to handle, and not an option for him.
Captain Defenestrator