Continuity mistake: Lois and Meg take the red car for their vacation at the spa, but while they are gone, Peter is seen driving it a few times. (00:08:00)
Audio problem: In the scene where Quagmire is bidding on the prostitutes panties, the auctioneer says that she had 9 STDs, but the closed captions have him saying, "She had 12 STDs." (00:03:20)
Continuity mistake: When Meg is waiting for Lois outside the hooters, she has a watch on her wrist. When she is talking with Lois, it just disappears after a couple of shots and we don't see it again. (00:11:10)
Continuity mistake: Pay attention to the items behind the police auctioneer. In the first couple of shots we see a statue of a knight on a horse to the left of the auctioneer. When the camera cuts to Peter, and then cuts back, the statue is gone. The statue is then back in the next shot. (00:03:20)
Factual error: When Meg and Lois are in the back of a police car they escape by opening the back doors and getting away. The rear doors of a police car can only open from the outside, for obvious reasons and this escape could not be possible.
Continuity mistake: When we see Meg and Lois in the mud bath, there is a clipboard next to the TV remote. However the clipboard soon vanishes. (00:05:30)
Continuity mistake: When Stewie gets out of the pool, he puts his brush down by the side of the pool and walks off, When we see him on the phone the brush and puddle of water by the pool has disappeared. (00:02:45)
Answer: Lacey Chabert was the actress who originally voiced Meg in early episodes. She left of her own accord due to being in school and other acting work; Seth MacFarlane has stated there was no tension with her leaving, but it makes for a handy joke for the show.