Continuity mistake: When Martin does his book report, on the blackboard it says 'An afternoon with Ernest Hemingway: Reflections by Martin.' But when Bart goes up to do his report, the blackboard is clean. (00:01:25 - 00:02:20)
Continuity mistake: Near the start, when Homer is going through the medicine cabinet and we see various items. He takes out various hair growth products, and then when we see what's left, the floss has vanished. (00:01:10 - 00:02:20)
Continuity mistake: When the Flanders and Simpsons first meet at the golf course, Flanders is wearing his usual long-sleeved green sweater over his shirt. After Homer says to him, "The fruit of my loins can beat the fruit of your loins any day of the week", the color of Flanders' sleeves is missing, making it look as if he's wearing a sleeveless pullover.
Three Men and a Comic Book - S2-E21
Continuity mistake: When Martin is tied to the chair near the end of the episode, the number of ropes tied to him change from four, then to three, and then back to four.
Continuity mistake: Bart's 1st grade drawing of cat on the fridge changes across the episode, especially its ears and whiskers. (00:04:50)
Continuity mistake: When Bart hands Ms.Krabbappel his final test, there are some shots going back and forth between their faces. During the first shot looking at Ms.Krabbappel, you can see a window behind her, and outside the window, there is no snow, even though there was a whole lot of it yesterday. During the next shot, the snow IS there. As the camera goes back and forth, the snow disappears and reappears.
The Simpsons Halloween Special: Tree House of Horror - S2-E3
Continuity mistake: When Homer is preparing the barbecue, he is wearing an apron that says "Mafia staff apron". After he goes to pick up the lighter fluid, it reads "Maffia staff apron", and after he has lit the barbecue, it is back to saying "Mafia".
Continuity mistake: When there is a zoom in of the house just before Bart gets up late, it has the old arch-shaped windows, but in the rest of the episode it has the normal windows. It's obviously a screen from Season 1. (00:06:00)
Two Cars in Every Garage and Three Eyes on Every Fish - S2-E4
Continuity mistake: The shot glass that Burns places on his desk disappears for several frames before reappearing. (00:05:45)
Three Men and a Comic Book - S2-E21
Continuity mistake: When Martin is tied up in the treehouse, at one point Bart takes the brick off the comic book and sets it down near Martin. When Bart and Millhouse fight, the brick disappears.
The Simpsons Halloween Special: Tree House of Horror - S2-E3
Continuity mistake: In Hungry are the Damned, when The Simpsons are on the spaceship and the aliens show them the food, there are 3 pots and two plates. Yet when the shot changes there are 4 pots and no plates. (00:10:25)
Continuity mistake: Bart is putting pool balls while training with Lisa, the 2 balls remaining on the table change from white to a pink/red. (00:14:20)
Homer vs. Lisa and the 8th Commandment - S2-E13
Continuity mistake: When all the kids run out of the back door, Homer drops a blue box. In the next shot it is a yellow box with red lines on the edges.
One Fish, Two Fish, Blowfish, Blue Fish - S2-E11
Continuity mistake: When Homer is given his plate of sushi, there are four pieces on his plate. Moments later, before he begins to eat, he has six pieces on his plate. (00:03:35)
Three Men and a Comic Book - S2-E21
Continuity mistake: When Bart, Martin and Milhouse start to fight, the Radioactiveman issue 1 that they were protecting has disappeared from the table. Then when Marge brings up some food, they all start eating. The table has disappeared altogether.
Homer vs. Lisa and the 8th Commandment - S2-E13
Continuity mistake: When Homer and Marge are discussing about unhooking cable, the time on the clock on Homer's bedside table changes between shots.
Homer vs. Lisa and the 8th Commandment - S2-E13
Continuity mistake: When all the kids are watching TV, we see Wendell, Martin and Milhouse. Absurdly they appear to be right below the ceiling in this shot - when in every other shot they are sitting on the sofa or standing.
Continuity mistake: Just before Bart's flashback, his shirt is orange, and the chair he's sitting on is blue. But in this episode, his shirt is a paler shade of orange and the chairs in the classroom are red.
Oh, Brother, Where Are Thou? - S2-E15
Continuity mistake: When Herb, Bart and Lisa are watching Itchy and Scratchy, Herb goes from wearing a t-shirt and shorts to a shirt and tie between shots.
Continuity mistake: The guardrail at the Springfield Gorge keeps changing between shots when Bart is about to make his big jump; in the first wide shot there is a short rail opposite the "stone ramp." Then in the Bart-POV shot from atop the ramp, the rail is much longer, and the parking lot and picnic area behind it have disappeared. And when Homer is actually jumping the gorge, the rail disappears altogether.
Answer: I'm not sure if this is the one you're thinking of, but an episode of "Ray Bradbury Theatre," called "A Sound of Thunder," dealt with a similar matter: a group of hunters travel back in time to hunt dinosaurs, only to find things have changed when they get back because someone stepped on a butterfly.
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