Character mistake: When James enters and exits the laboratory, the door has a sign on it that warns for radioactive materials. The laboratory actually contains a biological weapon. Therefore the door should be marked with a bio-hazard symbol. (00:41:00 - 00:42:00)
Continuity mistake: In Venice, a boat with a coffin passes Bond's gondola and when the coffin opens, the man has his left hand on his suit. In the next shot, he now has his hands joined together.
Continuity mistake: After the elaborate sequence showing each moonraker shuttle docking with the space station, a wide show of the station shows two shuttles frozen in space not attached to anything. The most prominent is the shuttle in the top foreground. The shot looks like a still photo with the exception of the spinning radar dish at the bottom of the station.
Factual error: When a real shuttle is launched (or any other large rocket) the exhaust must be deflected sideways and guided through massive tunnels or trenches so that it does not bounce back into the base of the vehicle and destroy it. The Moonrakers lift off from inside an enclosed structure with no means of guiding the massive exhaust plume safely away. The tiny tunnel through which Bond and Holly escape would have been utterly useless to vent the exhaust of a real shuttle. In common with other movies, the noise and violence of a real launch simply cannot be portrayed accurately.
Continuity mistake: Bond is in his boat being pursued by Jaws in another boat, and as they approach the raging waterfall, Bond activates the emergency hang-glider concealed within the roof of his boat. He flies away and there is no shot of his boat going over the falls, nor is his boat shown still in the water leading up to the falls when Jaws' boat approaches the falls. Jaws and his boat are shown going over the falls, but Bond's boat seems to have simply disappeared. [During filming of the scene Bond's boat got stuck on some rocks and never went over the waterfall as planned. The stuntman doing the handglider stunt would not do it again, so they had to make do with the film they had shot. They only had 3 boats to film the boat chase - one "hero" boat, one to film the hand glider scene, and a empty boat shell to go over the waterfall, which was damaged by the rocks. Still a mistake, but there's why.]
Factual error: Drax hides his station by "jamming" Earth radar. However, jamming involves blasting out noise to confuse radar. At the very least, it would alert authorities that something was up there.
Revealing mistake: When Bond is in the space station, the American shuttle is being attacked by a laser array. Bond thwarts the attack by activating a switch which causes the space station to decelerate, whereby it loses its spin and artficial gravity. People and objects start to move violently with respect to the station itself as a result of this. We see Bond and the operator being jerked back from the operations console. However, there are 5 actors close behind them who remain standing in the same position and do not move at all.
Plot hole: Near the end of the film Drax tells Bond he had his own shuttle hijacked because he needed it after another shuttle malfunctioned. OK then why didn't Drax just contact whoever he needed to before the Moonraker left on the 747 and have the working shuttle returned to his base before it left. He obviously had the time to get two of his people hidden in the shuttle so a few phone calls would have fixed his problem and the British government would have never had to involve Bond at all.