Trivia: At one point, the opening scene of the clone Alice in the simulated mansion was going to be longer and include re-creations of more moments from the original film. This was to try and confuse audiences and possibly make them believe that somehow they were seeing the wrong film and create a sense of unease. However, it was deemed far too long, and was trimmed down.
Trivia: Director Russel Mulcahy specifically chose to shoot much of the film in daytime, often in direct sunlight in order to both give the film a contrast to the first two, as well as to lend to a bigger feeling of dread and fear, since typically bad things in horror movies happen exclusively at night and day is portrayed as safer.
Trivia: At one point in production, the film was going to be titled "Resident Evil: Afterlife." This was dropped for the title "Resident Evil: Extinction." Interestingly, the original title was then re-used for the fourth film.
Trivia: The creature Dr. Isaacs turns into at the end of the film is modeled after the "Tyrant" creature from the original video-game which served as the end-boss.
Trivia: The scene where a zombie appears to be "domesticated" is a clear reference to the zombie-character "Bub" from George A. Romero's film "Day of the Dead." "Resident Evil: Extinction" also includes several other more subtle references to that film as well.
Trivia: When the man on the flame thrower is attacked by the ravens, he lets out a Wilhelm scream.
Trivia: When Alice's clone stops the lasergrid from killing the real Alice, there is a shot of the computer screen showing the disintegration of Isaacs, Dr. J. This is a reference to Jason Isaacs, who has a history of appearing in Paul W.S. Anderson movies. Anderson produced this movie, so the circle is complete.
