Continuity mistake: When swimfan85 is trying to talk to Ben and he tells her he has homework to get done, she is talking with the nick name swimfan85 but when she signs off it says "swimfan has signed off." They forgot to add the 85.
Factual error: Trevor - a Professor of Geology - boasts about having an article published in Scientific American, and that is not something any scientist would do. Scientific American is looked upon with slight disdain by the scientific community, considered to be a populist crowd pleaser. It is not even peer reviewed. Considering that he has just turned the geological and archaeological worlds on their heads he would have been better off publishing in Journal of Geological Research or Geology, both prestigious professional journals.
Continuity mistake: Hooper wears rimless eyeglasses, with the arms either attached at the upper corners of the lenses or at the sides of the lenses. If this didn't happen between shots within the same scenes, it could be presumed that Hooper has two different pairs of glasses and switches between the two, but they do indeed change between shots, such as when Mrs. Kintner slaps Brody, or even later, on the Orca. (00:36:05)
Continuity mistake: On the ferry, Rachel wears the purple/pink camouflage hoodie over her orange knit sweater with the colorful stripe sleeves, as usual. Now this is where things become strange. In the first shot as the trio come ashore, she is only wearing her orange sweater, she is not wearing the purple/pink hoodie - note the clear lack of fur hood. In the very next shot as they climb a bit more and then rest, Rachel is wearing the purple/pink hoodie - note the hood, but now it's on under her orange sweater. In the underwater shots she is also wearing it under the orange sweater. (This odd mistake has absolutely nothing to do with the very long wool cloak that Rachel wears in the next scene). (01:02:20 - 01:04:40)
Other mistake: In the slaughterhouse scene, after Harrigan has injured the Predator with his shotgun and Keyes reappears, the Predator throws its disc, and severs Keyes in half at the waist. We see his legs flop to the ground, and blood pour from above, but his upper half (torso, backpack and weaponry) mysteriously remain hovering out of sight. (01:21:50)
Factual error: Towards the end of the film, Solomon is trapped in a small Plexiglas box and fires his gun into the bulletproof sides numerous times, but the bullets don't ricochet or get embedded in the glass.
Continuity mistake: In the latter half of the movie, Picard looks at a picture of himself from his days as a Starfleet Academy cadet while Beverly looks on too. This picture is actually the actor Tom Hardy (Shinzon, Picard's clone) and he appears with a completely bald/shaved head. Showing Picard bald as a cadet completely contradicts the TNG series. In the TNG episode 'Tapestry', a flashback set in 2327 (the year Picard graduated from the Academy), Picard is shown with a full head of hair. Also, in the TNG episode 'Violations', a flashback set in 2354 shows Picard with a partial head of hair when he takes Beverly to see her dead husband Jack's body. (00:46:25)
Visible crew/equipment: When C-3PO is on the conveyor belt, if you look in the reflection in his head you can see the camera crew.
Continuity mistake: When Layla is hooked up to the lie detector that tracks the movement of her eye, she is looking around the room and blinking repeatedly, but the eye on the screen (which is supposed to be hers) never moves or blinks, even though the camera is still on her.
Factual error: Fitch, who professes qualifications in biology, genetics and biochemistry, says that they made Sil female because she's a natural predator and so she'd be more docile. He should retake his finals. In every single species of predator on earth - every single one - the females are the hunters, aggressors and killers. The males may be socially dominant but they are the 'docile' ones. There are no exceptions - and no human DNA was used to create Sil - they used synthetic DNA based on the instructions transmitted to them.