Character mistake: Baymax, a healthcare robot, says that his programming includes a database of 10,000 symptoms of disease. Yet, he issues the warning, "After eating, wait one hour before swimming." That warning, often given by parents to their children, has no basis in medical fact. People who do not get cramps after eating will not develop cramps by going swimming after eating: http://www.snopes.com/oldwives/hourwait.asp.
Character mistake: Debbie is doing an "All 80s weekend" on her radio show, and the film's soundtrack is based on exactly the same idea. Debbie plays 'Rudie Can't Fail' by The Clash. This is from the London Calling album, which was released right at the end on 1979 in most countries. The song was never released as a single in any year, so it's definitely a 70s song. What's interesting abut this mistake is that the soundtrack was selected by former Clash lead singer Joe Strummer.
Character mistake: When Tallahassee firsts meets Bill Murray, He says "six people left in the world and you're one of them." At that point they only know of 5 - the 4 main characters and Bill Murray.
Suggested correction: His character thinks there was another woman that Columbus hooked up with in the back of a FedEx truck.
Character mistake: After Charlie and Irene leave the Rhode Island station for New York, the female officer refers to her boss as Captain, when he is a Colonel.
Character mistake: In the scene where Ned talks to Janet after getting out of prison, she says "Jared this is what happens..." His name is Ned, not Jared. (00:08:00)
Character mistake: In the scene when Jennifer Aniston is driving in the parking lot to take her kids to meet Brooklyn Decker, she is driving a Chevrolet. At the end of the movie, when she's confessing to Nicole Kidman, she states that she drives a Honda.
Character mistake: After Gru tucks the girls in for the night, Dr. Nefario tells him that there are 48 hours until the rocket's scheduled launch. The rocket launch, then, should have taken place at night, around the time the girls go to bed, two days later. The rocket, however, launches during daylight hours.
Character mistake: In the scene where the dentist is doing a root canal, Bloat says "rubber dam and clamp installed?" and another fish replies "yes", but when the picture goes back to the dentist and patient you can plainly see that there is not a rubber dam on the patient. A rubber dam is a large piece of latex attached to a metal frame, to keep water from the dental handpiece from going into the patient's mouth. Although all of the dental jargon in the film is precisely accurate, this device would have been very noticeable.
Character mistake: The so-called cobalt chlorium (.) G, which is supposed to be used in the Russian doomsday device, has, according to the Russian ambassador (and Dr. Strangelove), a half-life period of 93 years. He then states that it would contaminate Earth for 93 years. However, per definition half of the radioactivity would still be left after this period. (00:47:30)
Character mistake: When the little boy is reading his report about Abraham Lincoln, he states that Lincoln was born in a log cabin in Illinois. Lincoln was actually born in a log cabin in Kentucky.
Character mistake: At the football players funeral, the guy on the left is still breathing, despite being dead.
Character mistake: Gru doesn't recognize Nefario at the record shop, despite meeting him at Villain Con in the Minions movie. And given the fact that he can recognize all of his Minions without even asking them who they are, he should definitely remember seeing Dr. Nefario.
Character mistake: In the scene where the Panthers are being introduced, the announcer states that one boy is "Walter 'The Hook' Coster", and another is "Frank 'The Razor' Schmidt". But in another scene, when one of them is batting, he says Frank Coster. Although they look exactly the same, he accidentally mixed the two names together. There is no Frank Coster. (01:12:50 - 01:19:15)
Character mistake: Sandra Bullock's German is very good, but not perfect. She says about her husband, "Gestern hat er seine Schuhe in den Gefrierschrank gestellt," ("Yesterday, he put his shoes in the freezer"). Immediately afterwards, she says "seine Schuhe ins Gefrierschrank," ("He put his shoes in the freezer"). The word Gefrierschrank (freezer) in German is masculine and can never be preceded by the accusative case contraction "ins", the contraction for "in das." She just changed the gender of the word Gefrierschrank (freezer) from masculine in the first sentence (correct) to neuter in the second sentence (incorrect). (01:40:05)
Character mistake: While pitching his shrinking machine to NASA Szalinski claims that reducing the size of a rocket's payload would result in "staggering" savings in the fuel required at takeoff. However, he makes it clear that his machine works by reducing the space between atoms, meaning that the shrunken object weighs the same as the original. Weight is the critical factor in calculating fuel consumption, not size. Anyone at NASA would pick up on that instantly.
Character mistake: When the mathletes advertise their poster on the desk it reads 3.14... then they make up numbers instead of following the actual number of pi. (00:01:00 - 00:03:00)
Character mistake: During the game against the Cardinals in the playoffs, the announcer says that Averman passed to Guy who then scored. First, Guy does pass the puck back to Averman, but then he passes it to Banks who scores the second goal, propelling them to the playoffs.
Character mistake: In the Air Force One scene, when lightning destroys one of the plane's engines, one of the pilots tells a co-pilot to inform Metropolis Airport that the president is on board the plane. The crew is unnecessarily repeating themselves: just a few moments before, they radioed in that "Air Force One" was on approach; the plane would only have that call sign if the president was on board.
Character mistake: In the scene where Aaron visits Daphne at the hospital, the lower left x-ray in the background is upside down. (00:18:15)
Character mistake: In the scene where Debbie is sitting in Dr. Pellegrino's office, she finds out she is pregnant. Dr. Pellegrino's name is spelled Pellagrino on his white medical jacket and Pellegrino on his desk.