Plot hole: When Zach Young's grandfather died, Zach was said to be the sole heir of the fortune. However, Noah Taylor (the grandfather) had a daughter that appeared several times while Mike Delfino was looking for Deirdre. Where was Kendra Taylor while Zachary Young was spending Noah's fortune on dresses for Gabrielle Solis? Why didn't she claim her share? She simply disappeared.
Other mistake: Season 04, Episode 14: In the scene where Lynette and Tom are fighting about Lynette having taken Kayla to see a therapist, and Kayla walks away, you can hear Tom yelling about Lynette having a distorted reality and that she can't pull crap like that. In the scene where Kayla comes back into the house after conning the twins into jumping off the roof, Tom and Lynette repeat the same dialogue again.
Factual error: Season 2, episode 20: Gabrielle visits Dale, her adopted child's natural father, at his high school and interrupts a pep rally for the football team's upcoming game. Dale, the team's Quarterback, even says that in the last game, he threw for 260 yards. The problem is that it is spring. Dale has just returned from a week in Florida for Spring Break. Football season is over. Basketball season should be over or ending soon. There couldn't have been a pep rally if the season is over.
Continuity mistake: When Betty is shown the crime scene photo of Melanie's body, Melanie is inches away from a pallet and the jacket covers most of her torso leaving only the right arm exposed. In the flashback scene, Melanie is feet away from the pallet and the jacket mainly covers her chest and face, leaving both arms uncovered.
Continuity mistake: On the note Mary Alice receives that leads to her suicide, the position of the three sentences changes throughout the series. In episode 1.1 (Pilot), all three lines are written on the top half of the note (above the crease), but in later episodes the first two lines are on the top and the third is on the lower half. The left margin also gets smaller, and the handwriting varies slightly.
Factual error: In the ep in season four where Victor drifts ashore, someone calls the police officer at Gabrielle's home and informs him that Victor has been found. The officer answers the call, listens for about one second and then hangs up. In that one second he's gotten four sentences of information to pass on to Gabrielle about her husbands whereabouts. There wouldn't have been time to tell him so much in so little time.