Factual error: The contract Stone and his team force Carlton Wood and Harry Fielding to sign guaranteeing Fowler's widow the royalties from his invention for life is signed under duress and is therefore invalid. It is hard to believe that none of Stone's team don't know this, but it is impossible to believe that Carlton Wood wouldn't.
Plot hole: When Zach Young's grandfather died, Zach was said to be the sole heir of the fortune. However, Noah Taylor (the grandfather) had a daughter that appeared several times while Mike Delfino was looking for Deirdre. Where was Kendra Taylor while Zachary Young was spending Noah's fortune on dresses for Gabrielle Solis? Why didn't she claim her share? She simply disappeared.
Factual error: When House is looking over his whiteboard of symptoms for the swimming patient, the symptom "Intercranial Hemorrhage" is shown on the board. However, this is an error. The correct term is "Intracranial Hemorrhage." Anything inside the head is referred to as "intra" not "inter." This is a common mistake for laypeople, however the highly trained and knowledgeable Dr. House should not have made that error. (00:31:25)
Character mistake: When Mac, Stella, and Danny are trying to determine where the fired bullet entered the train car, none of them are wearing rubber gloves. But even though they're not handling any evidence, they're still processing a crime scene. (00:05:00)
Continuity mistake: When Jack speaks to Michael and Jin, as they build the raft, and then when he walks up the beach and inquires about Sawyer's trouble with his head, the backpack that Jack carries on his back is nylon, black/green with white trim. Yet, when Sawyer asks, "Sensitivity to light, that bad?" the backpack is suddenly transformed into solid black leather, of an entirely different style. Then, in following shots it jumps back and forth. (00:16:40)
Continuity mistake: When the video of Kimmy plays on the school announcements, and she talks about Duncan being hung up on Veronica, there is a cut to Duncan reacting with raised eyebrows in the foreground, while Veronica can be seen in the background with a passive expression. Then it cuts to a close-up of Veronica having a visible reaction with her whole face falling. But since Veronica and Duncan were reacting to the same thing, Veronica's reaction should have been visible in the first shot as well.
Factual error: In episode 17 there are some scenes showing sick 4400s all around the world. One of them is being carried into an ambulance car in Frankfurt, Germany. The ambulance car's number plate begins with the letters FM meaning Frankfurt am Main. The correct abbreviation for Frankfurt am Main on German number plates is F - not FM.