The Calzone - S7-E20
Continuity mistake: This mistake is in The Calzone episode. Towards the end when George walks in and his boss is looking around for the smell of calzones, George is holding a bag in his hand. In the next shot that shows the back of the boss's head the bag is now on top of a box that George is carrying. When it goes back to a close up the bag is in his hand again.
Chosen answer: George does mention his brother in the episode "The Parking Space". They actually really never mention anything that contradicts the fact he had a brother though, it just isn't mentioned.