Audio problem: When Claire is in the car about to leave hospital, she turns around to tell Emma to put her seat-belt on. Though you hear her say "fasten your seat-belt sweetheart" - her lips aren't moving when you hear "sweetheart".
Audio problem: When Claire and Marleen return from lunch and both are greeting baby Joe, you can hear him screaming his head off. However, when Claire hands him back to Peyton, you see his face and he is not distressed at all (even though you can still hear the crying). (00:44:05 - 01:00:05)
Continuity mistake: The baby's burping pad disappears and reappears from Claire's shoulder after Peyton pretends to save the baby from choking on the earring. (00:25:50)
Factual error: When Marlene goes to the greenhouse and is killed by the falling glass, this would never have happened. It is a federal law that all greenhouses, skylights, and entry-ways are to be made of safety glass. The glass would have to have been made of either a Tempered glass, which breaks in a thousand pieces, like a car window, or Laminated glass, which cracks but does not fall apart, like a car windshield. Neither one of these glasses would have killed her. Surely, law abiding citizens like Clare and her Husband would have followed the zoning laws that came along with building their greenhouse.
Other mistake: When Peyton and Emma are watching a scary movie in Peyton's room, Emma is eating popcorn. However, if you watch her mouth, she isn't actually eating anything (just doing an incredibly bad job of pretending to). (00:34:15)
Audio problem: In the early hospital scene, the TV sound can be heard but the TV had the "MUTING" caption on.