Continuity mistake: During one of the scenes when Brad Pitt arrives home, he is driving a Lincoln Town Car, not his Cadillac. This is the car that he doesn't get until later, when he steals it and drives home during the scene when they crash the cars into each other at the end of the driveway.
Continuity mistake: After the botched hit in Mexico, Jane returns to her office, a little beaten up, and her associates tend to her wounds. Particularly clear is an injury to her right shoulder - it has bled enough to mark her singlet top, and is covered by a large piece of plaster. Yet when she dances with John in the restaurant, only a few hours later, there is no sign of plaster or wound.
Continuity mistake: When John and Jane steal their neighbor's minivan (after their house explodes) and back out the driveway, an assassin jumps onto the back. John hits the brakes and the assassin falls off onto the ground beside the van. In the next shot it is implied that the van runs over the assassin (two bumps), but John has not turned the steering wheel.
Continuity mistake: During the car chase on the freeway, Jane forces one of the pursuing cars off the road by driving, with it, through those large barrels of water near freeway exits. Water cascades over the cars; one interior shot shows that it's virtually impossible to see through the windscreen. Yet in the next shot, a few seconds later, all the cars are completely dry.
Continuity mistake: When Pitt is chasing after Jolie, he crashes through a fence and fires his gun, hitting the car's windshield. To the left of where Pitt is, you'll notice that there's one rail missing in the middle. When he climbs through the fence to the street, the fence rail has returned, and the hole left by Pitt is now slightly wider, just enough for him to climb through.