Continuity mistake: In the scene where the Nemesis kills the 13 S.T.A.R.S members, after it blows up the sniper on the roof an additional S.T.A.R.S member can be seen outside the building on the right who wasn't there earlier. He then disappears shortly afterwards.
Continuity mistake: At the end of the film when Alice gets her memory back, she grabs a pen and points it very close to a man's eye, then the camera changes shot still looking at Alice and the man but the pen is much further away from the eye than before.
Continuity mistake: After the gas explosion in the school, Angela reveals that Alice is infected. The woman cop asks "When were you gonna tell us that?" and the next shot shows Alice with burns/blood on her upper left arm. In the next shot as Alice goes to sit down, the severity and position of the burns/blood changes. (00:56:50)
Continuity mistake: When the girl is being chased by the zombies (just before we meet Carlos) the keypad for the door is right next to it. When she tries to enter the code, it is suddenly next to the small grey box. (00:09:30)
Suggested correction: It's next to that small gray box (appears to be a light switch) in every shot. At no point is it anywhere different.
Continuity mistake: Watch the left side of the mouth piece in Alice's mouth when she is in the tank at the end. In the shot up close to her left there is a plastic support going up, in the next shot of her right the support is pointing down, and after the scientist says "can you hear me?" and the shot is close to her, the support isn't even there. (01:20:30)
Continuity mistake: Toward the end, Major Cain storms aboard the helicopter, shouting "Why haven't we taken off, yet?" The shot switches to LJ (Mike Epps)in one of the pilot's seats. As he says, "Because I normally drive Cadillacs" he punches out at Cain with his left hand. In the reaction shot, however, as Cain flies backward, the punching hand is LJ's right hand. (01:12:55)
Continuity mistake: Nemesis has an ammunition counter for his Vulcan cannon. When Nemesis is shooting at Peyton on the bridge, his counter stops at 3997 rounds. Almost immediately he begins shooting at Jill, but now the counter reads 3688. (00:43:20)
Suggested correction: The counter doesn't "stop" at 3997, the audience's POV changes while Nemesis is still firing, and the counter is last seen at 3978. The camera switches back to Nemesis' HUD roughly 5 seconds later when it is at 3688. Considering Nemesis is firing for some of the 5 seconds between when we can see the counter, and that miniguns can fire 100 rounds per second, none of this is impossible or even implausible.
Continuity mistake: A zombie hits its head on a tombstone, which falls over. In the next shot, it's upright again. (00:32:40)
Suggested correction: Could easily be another zombie and another stone.
Continuity mistake: When Alice and the group are going to raid the Umbrella guards and steal the helicopter, one of the men looks through binoculars with night vision. He looks at the helicopter, then looks to the right of the helicopter, yet in the next scene a second later, his head is in the same position as it was when he looked at the helicopter, before he looked to the right.
Continuity mistake: As Alice is attacking the guards around the helicopter with the batons, she switches from holding them low to holding them high between shots right after she knocks down the last guard. There isn't enough time or any reason for her to do so in the second offscreen as the others arrive. (01:04:15)
Continuity mistake: At the surplus store as a hand picks up a weapon, it is clear that the person is wearing jeans. The next shot is of a person wearing a lab coat and after that we see Alice getting dressed. (00:18:25)
Continuity mistake: When Jill Valentine and Angie are running from the dogs after turning on the gas, Jill kicks the left side of the double doors open. However, when she turns around to see if the match ignited the gas, she has the right door open. When Jill Valentine realizes Alice light a cigarette she starts running, again out of the right side of the door. (Looking at the doors from the kitchen to the cafeteria). (00:56:00)
Continuity mistake: Near the end, at the chopper crash site, the Umbrella man lifts the corner of the sheet covering Alice's body. From the high zoomed out shot, the guard is facing the waterfall, while the next shot he is facing the body. (01:18:50)
Continuity mistake: When Alice slides on the floor, she shoots up a hole in the wall and goes down it, dislocating a finger on her left hand in the process. In the next shot she straightens it out, and the finger is on her right hand.
Continuity mistake: In the DVD, at the climax, just prior to when Alice is forced to fight Nemesis, she has a conversation with Thomas Kretschmann (the dude with the leather coat). During the conversation, one shot shows Alice with blood trickling down her neck and some bruises on her face after she previously had no injuries. Moments later, her face is back to normal. Later, during the fight with Nemesis, you see that that is where she sustains her injuries.
Continuity mistake: Just before Nemesis starts shooting at Alice after shooting at Valentine, the counter on his gun shows 0000 rounds left. (00:42:10)
Continuity mistake: Watch the scene where Alice almost pokes the scientist with the pen. In the close up shot of the guy's face, she almost poked him in his left eye. In the far shot, the pen is being pointed at his right eye. (01:23:30)
Continuity mistake: When Nemesis blows up the STARS sniper on the roof of the theater, the size of his rocket launcher changes drastically. (00:37:55)
Continuity mistake: When Alice escapes from Nemesis falling into the garbage, she shows both hands with her fingers in good condition. Yet in the next shot, she has a very badly broken finger. (00:45:30)
Continuity mistake: When they're in the school and they split up, Terri walks into the classroom and the map at the front of the classroom has bloody hand prints on it. When Jill Valentine walks into the same room later, there are no hand prints on the map.
Suggested correction: It's two different maps on two different walls.