Plot hole: *SPOILER* Toward the end of the movie, Ryan Gosling goes to Hopkins' house where Hopkins is tricked into not only confessing again, but giving Gosling the murder weapon, after they are back in court and Gosling is the acting prosecutor. This would be a conflict of interest due to the fact that Gosling is a witness.
Suggested correction: First, the gun that Beachum took from Crowford's house was not the murder weapon. It was Crowford's unfired gun. He only took it out of the fear of his life. Second, Beachum entered Crowford's house with police supervision. If he plays it by the book, Crowford's confession is valid. In that case, supervising officers will stand witness, along with a recording confirming their testimony. Third, Beachum doesn't need the confession anymore. He was amply clear on that matter.
Continuity mistake: In the scene when Dawn is sitting on the edge of the tub after her shower, her "purity ring" switches from her left hand to her right and then back to her left hand in between close up and wide angle shots. (00:40:25)
Deliberate mistake: So right before the containment team seal up the window with the tarp, the SWAT is shown having police dogs. The virus (which came from a dog in the first place) can be transferred through saliva. The SWAT obviously overlooked the fact that the potentially infected people who might escape could be bitten by the dogs.
Continuity mistake: The train that Carol takes from Washington to Baltimore is an Amtrak Acela Express train, as can be seen in the station and interior shots. The exterior shot of the train passing by shows a different type of Amtrak train.
Factual error: The license plate on the blue Ford Taurus is 674-H2T. Format for New Mexico standard issue yellow plates is 123-ABC (three numbers, the Zia sun, followed by three letters).
Continuity mistake: In the opening scene, the car's shadow changes with each shot from very long to very short.
Revealing mistake: At 39:55, actress Jaime King gets out of the shower, and she has just reached for her robe, and then on the bottom right corner of your screen you can see a bit of the flesh-colored body suit she's wearing. Continue to 40:00 where you see it again. Continue to 40:05-40:09 where you can see it, without slowing or stopping frame. (00:39:55)
Other mistake: The film's set in Seattle but was filmed in Canada. This is evidenced by things like a Canadian red striped postal box as well as cars with Canadian license plates.
Other mistake: Chris' leg cast was thigh-high. When he got out of bed (and used crutches), his cast was OVER his pants. His pants' leg did not appear to be cut off - it was securely under the cast and never changed despite all the fighting/activity he engaged in. (00:36:22)
Continuity mistake: While McGahan is leaving the trailer with the widow (after giving his speech on heaven and hell) he closes the door. The next shot of him outside, the door is now wide open.
Continuity mistake: Standing in the subway talking about what the creatures were, the blood from the infected tract wound from the heroin needles is completely gone, as well as the entire wound itself. (00:46:30)
Continuity mistake: The two protagonists are having a conversation at a long table. Michael Caine sends a bottle of wine rolling across the table. Jude Law opens it and pours. The bottle label now faces him. After Caine says the line "I've never heard of an Italian called Tindale", Milo hasn't moved but the bottle faces the camera now. There's another subtle change in angle and level of the liquid a bit later when Caine says that his wife would get the "Tindelini" last name. (00:09:20)
Visible crew/equipment: At the shootout in the trailer park near the end, the redneck neighbour comes out of his trailer and his shotgun jams. Immediately after, he is shot with a machine gun mounted in the back of a white Mustang. Right at the end of his expletive-filled final line, you can see the safety cable from the pulley that jerks him backward through the wall behind him. (01:19:55)
Continuity mistake: Pickles is killed by multiple stab wounds to the chest and neck, as well as being scalped. But in the scene where Willa finds him, and when he is seen in his body bag, there is not a drop of blood to be seen anywhere on his face or clothes.
Other mistake: In a scene when Deborah Martin takes a photo in the mirror the camera's position would'nt allow for the photo to be taken properly, as it does later on in the film.
Continuity mistake: When Andy Konsong discovers his brother's mutilated body in the bloody swimming pool, he vomits, then tries calling for help on his cellphone. As he makes his call, the gigantic crocodile lunges out of the pool and bites off Andy's arm, cellphone and all, above the elbow. Andy screams, staggers and lands on his back, but his only injury thus far is his severed right arm. His mouth is not bloody at all, nor should it be. The camera cuts to another angle as the crocodile lunges a second time; but, before it even enters the frame and bites into his legs, Andy's mouth is suddenly full of blood, his teeth are bloody, and blood is streaming down his chin, even though he has suffered no abdominal injuries.