Character mistake: When Olivia and Dr Galina are in the bathroom, Galina mentions an umbilical chord, from a baby whose mother died (Nadia), that contained Olivia's mitochondrial DNA. Mitochondrial DNA comes from the mother, so Nadia's Mitochondrial DNA came from Letha who got hers from Marie, absolutely nothing to do with Olivia.
Continuity mistake: When the video of Kimmy plays on the school announcements, and she talks about Duncan being hung up on Veronica, there is a cut to Duncan reacting with raised eyebrows in the foreground, while Veronica can be seen in the background with a passive expression. Then it cuts to a close-up of Veronica having a visible reaction with her whole face falling. But since Veronica and Duncan were reacting to the same thing, Veronica's reaction should have been visible in the first shot as well.
Revealing mistake: When the first scene at Emma's hideaway was shown, obviously the two characters Emma and Jessica were filmed seperately on the couch and then the film was put together (as both are played by Angela Lansbury). However Jessica did a lot of moving while she was talking, so Emma was looking straight across at where she had been, despite her bending down while she talked.
Factual error: In episode 17 there are some scenes showing sick 4400s all around the world. One of them is being carried into an ambulance car in Frankfurt, Germany. The ambulance car's number plate begins with the letters FM meaning Frankfurt am Main. The correct abbreviation for Frankfurt am Main on German number plates is F - not FM.
Continuity mistake: In the episode "Lost Time," when the professor stands up in the holding cell after Jack tells him that someone saw Skye at 10:30, he slams his chair back causing it to tip over. In the next shot the chair is upright, then when he goes to sit back down, it is again on its side.
Revealing mistake: During the scene when Mr. Lyle is talking to the General (butcher character), his glove that he wears on his hand is removed to make a point about his thumb having been cut off. In the next shot, we see Mr. Lyle walking around the desk and putting his glove back on, and you can see his thumb folded under his hand as if the actor was trying to hide it and did not realize it could been seen from the camera angle.
Plot hole: Laura successfully knocks out both bad guys, steals their van and crashes through the warehouse doors. The van doesn't stall, but inexplicably, she stops it, gets out and runs away on foot, even though the baddies are coming to and coming after her. Not the option you'd expect a kidnap victim to choose: most people would floor it and keep on driving. (00:23:40)
Continuity mistake: When Anne and Evert are driving toward the Norwegian/Swedish border, Anne pulls back the rug in the back of the sled, and discovers the dead Bjørn. He is then flat on his back, staring upwards. Moments later, when the Swedish border guards pull back the rug to look at the corpse, he is face down. No one touched him, and the sled did not bump enough to roll the body completely over.