Continuity mistake: When surrounded by police and a garbage truck, Frank drives his car from the overpass onto the passing transport trailer below, then lands behind a hatchback and in front of two cars - a white compact with a sunroof and a grey hatchback. In one specific shot from atop the trailer, as Frank rolls his window down (before he requests the gun) the only vehicle behind Frank's car is the white compact, which is at the trailer's rear. Note things such as the trailer's safety bars, and the view through the compact's windshield for starters. That grey hatchback is back when the ramp is lowered, for the ensuing crashes. (00:08:20)
Revealing mistake: Gracie hugs the Russian waitress in order to have a better view of the disc hand-off appear on the monitor. As she raises her left hand that holds the book/camera lens, we see that the digital feed that appears on the monitor stays steady and level, even though she is raising the book/camera lens higher and closer to her face. Obviously the feed that we see on the monitor is not taken from the book/camera lens. (00:04:10)
Continuity mistake: When Eliot Ness is at Jim Malone's house for the first time, Malone's collar is opened, then buttoned, then open again.
Continuity mistake: Towards the end, Denzel drives his car into 2 cars trying to get Ethan off the hood. After that scene ends you see Denzel driving the same car and the front and rear of the car look nothing like they did when he was crashing into the cars.
Factual error: After the intruders flood the panic room with propane, Jody Foster's character gets a lighter and ignites the propane causing it to burn along the ceiling. This would be impossible as propane is heavier than air and would sink to the floor rather than rise up to the ceiling. Lighting a flame in that room should have caused anyone in the room and on the floor to be engulfed in flames almost instantly.
Continuity mistake: When the two female characters enter the fancy hotel room, they make a point to say they will only be there for a couple of minutes. It is daylight when they go in. The visit is cut short (the one that's supposed to be a few minutes long) because of a gun battle in which one of the women dies and the other escapes. The escaped one gets out through the roof into an evening's sky. There's still light visible, but for a visit that lasts all of 4 minutes, it's far too quick a change. (00:23:00)
Plot hole: Harry tells Doc Ock that in order to find Spider-Man he must find Peter first. Doc Ock finds Peter with Mary Jane in the cafe and throws a car through the window straight at them, then later throws Peter against a brick wall. Any normal person would've been killed instantly (or very badly injured), and Doc Ock doesn't yet know that Peter is Spider-Man. Given that Peter is his only lead on Spider-Man, it makes no sense that Doc Ock would try to kill him.
Other mistake: When Catherine breaks into Crown's house, her assistants immediately get to work on the security panel. When the first assistant touches the panel, it falls off the wall and he has to quickly push it back into place.
Factual error: When Swagger is fleeing from the police in the car wash after being shot, the radio says that he is at a car wash at 9th and Girard. There is no such intersection. On Girard Ave, 9th street picks up south and north of that street.
Continuity mistake: At the Gator Motel, after Cledus and Bandit get part of the money, when Bandit starts crying about Frog and blows his nose into the money, there is a side shot showing a wad of bills in Bandit's shirt pocket before he actually puts the bills into his pocket in a following shot. (00:12:45)
Continuity mistake: In the scene at the bar with Gideon when the black guy pours Gideon a drink it is only about 1/3 full. When Gideon drinks it in the next shot it is almost full.