Factual error: After the intruders flood the panic room with propane, Jody Foster's character gets a lighter and ignites the propane causing it to burn along the ceiling. This would be impossible as propane is heavier than air and would sink to the floor rather than rise up to the ceiling. Lighting a flame in that room should have caused anyone in the room and on the floor to be engulfed in flames almost instantly.
Factual error: The mother tells the daughter to keep warm and drink water. In fact that would lower the blood sugar faster. This method is used for high blood sugar to lower it back to normal.
Factual error: The portrayal of Sarah's type-1 diabetes is loaded with inaccuracies. We saw her eating pizza the previous evening and along with this any sensible diabetic would have injected herself with enough insulin to last through the night, to cope with the sugars in the food she'd eaten. But in the panic room just a few hours later, she apparently needs another dose - wrong. If her condition was due to stress, she would have needed sugar or a glycogen injection, not insulin. In response Meg searches for sugary food to give Sarah. That's correct, but next thing Meg wants to inject Sarah with insulin, which would kill any diabetic in such a state. Finally, when becoming hypoglycemic Sarah thrashes about, apparently having an epileptic fit instead of what would really happen - she would just become very sleepy, lose consciousness and go into a coma. All this demonizes diabetes into a convenient scary plot device but in reality the condition is quite mundane - typical Hollywood.
Factual error: You would never give insulin to someone with low blood sugar. It would kill them. (02:53:12 - 02:54:00)
Factual error: In the scene where Kristen Stewart is flashing SOS in morse code through the hole her mother asks "where did you learn that" she then replies "Titanic." In the movie 'Titanic' they correctly used the proper distress signal of the time which was actually CQD (CQ is Code for 'All Stations' and suffixed by 'D' for distress). CQD in Morse code is -.-. -.- -..
Factual error: When the burglars use the crowbar to break through the roof hatch, the security system display changes from "System Armed" to "Zone 19 Disabled" which can only occur when the zone is disabled by the user. Additionally, the alarm should have sounded immediately when the sensor on the hatch was broken. If the circuit had already been disabled then the security system would not have reacted by saying "Zone 19 Disabled."