Soon-to-be divorced Meg and daughter Sarah move into a luxurious NYC townhouse, complete with a panic room—a steel enclosed security space equipped with sensors, closed circuit TV, phone (not yet hooked up), toilet, supplies, etc. During their first night in the house, three men, Junior, Raoul, and Burnum, break in. Expecting the house to be empty, they’re intent on finding something hidden inside the panic room.
Meg wakes up and goes to the bathroom. She spots the three on the security camera. She awakens Sarah and they lock themselves inside the panic room. They’re safe, but cannot stay inside long. Sarah is diabetic and her insulin kit is in her bedroom. If they can’t get to it soon, Sarah will slip into a coma and die. The intruders have no intention of leaving and are working on a plan to get into the panic room.